Results 31 to 40 of about 67,041 (267)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Performance Prediction of OWC Type Small Size Wave Power Device with Impulse Turbine

Journal of Fluid Science and Technology, 2008
This paper investigates a small size wave power device with an impulse turbine installed in the breakwater near Niigata Port, Japan. The device consists of an air chamber, a turbine, a generator and pressure-relief valves.
Masami SUZUKI, Manabu TAKAO, Eiji SATOH, Shuichi NAGATA, Kazutaka TOYOTA, Toshiaki SETOGUCHI   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Application of Time-Difference-of-Arrival Localization Method in Impulse System Radar and the Prospect of Application of Impulse System Radar in the Internet of Things

IEEE Access, 2018
The impulse system radar is based on the generation, transmission, radiation, receiving, data collection, data processing, and imaging of impulse signals.
Longfei Dang, Hongchun Yang, Baohua Teng
doaj   +1 more source

Developmental Traits of Impulse Control Behavior in School Children under Controlled Attention, Motor Function, and Perception

Children, 2021
This research surveyed the characteristics of the developmental traits of impulse control behavior in children through parent-report questionnaires.
Hsin-Yung Chen, Ling-Fu Meng, Yawen Yu, Chen-Chi Chen, Li-Yu Hung, Shih-Che Lin, Huang-Ju Chi   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Rolling Bearing Incipient Fault Detection Based on a Multi-Resolution Singular Value Decomposition

Applied Sciences, 2019
The periodic impulse characteristics caused by rolling bearing damage are weak in the incipient failure stage. Thus, these characteristics are always drowned out by background noise and other harmonic interference.
Jiesi Luo, Shaohui Zhang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Current Sensor with Optimized Linearity for Lightning Impulse Current Measurement

Sensors
Impulse current measurement technology is widely used in various applications, including lightning protection monitoring in power systems, welding current measurement in aircraft and shipbuilding industries, as well as high-current measurement in pulsed ...
Wenting Li, Yinglong Diao, Feng Zhou, Zhaozhi Long, Shijun Xie, Jiawei Fan, Kangmin Hu, Zhehao Wang   +7 more
doaj   +1 more source