Results 61 to 70 of about 64,993 (239)

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Frontal dysfunctions of impulse control – a systematic review in borderline personality disorder and attention deficit hyperactivity disorder

Frontiers in Human Neuroscience, 2014
Disorders such as borderline personality disorder (BPD) or attention-deficit/hyperactivity disorder (ADHD) are characterized by impulsive behaviors. Impulsivity as used in clinical terms is very broadly defined and entails different categories including ...
Alexandra eSebastian, Patrick eJung, Annegret eKrause-Utz, Klaus eLieb, Christian eSchmahl, Oliver eTuescher, Oliver eTuescher   +6 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

The temporal impulse response function during smooth pursuit

Vision Research, 2009
Recent studies indicate that the extent of perceived motion smear is attenuated asymmetrically during smooth pursuit eye movements, based on the relative directions of the target and eye motion. We conducted two experiments to determine if the reduction of perceived smear during pursuit might be associated with an acceleration of the temporal impulse ...
Tong, Jianliang, Ramamurthy, Mahalakshmi, Patel, Saumil S., Vu-Yu, Lan-Phuong, Bedell, Harold E.   +4 more
openaire   +2 more sources

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

On the Impulse Response of Singular Discrete LTI Systems and Three Fourier Transform Pairs

Signals
A basic tenet of linear invariant systems is that they are sufficiently described by either the impulse response function or the frequency transfer function. This implies that we can always obtain one from the other.
Qihou Zhou
doaj   +1 more source

An Impulse Response Function for Evaluation of UWB SAR Imaging

IEEE Transactions on Signal Processing, 2010
Based on analysis of a point target imaged by different synthetic aperture radar (SAR) systems, the commonly used impulse response function in SAR Imaging (IRF-SAR)-a two-dimensional (2-D) sinc function-is shown to be inappropriate for ultrawideband-ultrawidebeam (UWB) SAR systems utilizing a large fractional signal bandwidth and a wide antenna ...
Viet Thuy Vu, Thomas K. Sjögren, Mats I. Pettersson, Hans Hellsten   +3 more
openaire   +3 more sources

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

A simplified approach for simulating pollutant transport in small rivers with dead zones using convolution

Journal of Hydrology and Hydromechanics
In the paper an alternative method to solve the one-dimensional advective-diffusive equation describing the pollutants transport in river with dead zones is presented.
Szymkiewicz Romuald
doaj   +1 more source