Results 51 to 60 of about 415,160 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Contribution of Growth and Interest Rate Differentials to the Persistence of Real Exchange Rates. [PDF]

This paper employs a new methodology for measuring the contribution of growth and interest rate differentials to the half-life of deviations from Purchasing Power Parity (PPP).
Dimitrios Malliaropulos, Ekaterini Panopoulou, Nikitas Pittis, Theologos Pantelidis   +3 more
core   +3 more sources

Surrogate impulse ground motion for practical simulation of critical nonlinear structural responses

Frontiers in Built Environment
Impulse-based representations of earthquake ground motions provide an efficient framework for evaluating critical nonlinear structural responses. However, the direct use of ideal impulse ground motions expressed by Dirac’s delta function may excite all ...
Hiroki Akehashi, Mao Kinoshita, Fumiya Ueno, Koji Yamato, Yusuke Ehara, Tatsuhiko Maeda   +5 more
doaj   +1 more source

Investigation of the Physical Mechanism of Acoustic Attenuation in Viscous Isotropic Solids

Micromachines, 2022
The traditional acoustic attenuation coefficient is derived from an analogy of the attenuation of an electromagnetic wave propagating inside a non-ideal medium, featuring only the attenuation of wave propagation. Nonetheless, the particles inside viscous
Lin Fa, Lili Li, Hong Gong, Wenhui Chen, Jing Jiang, Guoqiang You, Jifeng Liang, Yandong Zhang, Meishan Zhao   +8 more
doaj   +1 more source

Closed form metrics to accurately model the response in general arbitrarily-coupled RC trees. [PDF]

, 2003
Closed form expressions are presented for the first and second moment of the impulse response for arbitrarily-coupled RC trees with multiple drivers, and used to generate accurate second order estimations of the transfer function from any driver to the ...
Elassaad, Shauki, Pamunuwa, Dinesh B.
core   +1 more source

The temporal impulse response function in infantile nystagmus

Vision Research, 2008
Despite rapid to-and-fro motion of the retinal image that results from their incessant involuntary eye movements, persons with infantile nystagmus (IN) rarely report the perception of motion smear. We performed two experiments to determine if the reduction of perceived motion smear in persons with IN is associated with an increase in the speed of the ...
Bedell, Harold E., Ramamurthy, Mahalakshmi, Patel, Saumil S., Subramaniam, Shobana, Vu-Yu, Lan-Phuong, Tong, Jianliang   +5 more
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

EFFECT OF SHOCKS OF AGRICULTURAL TERMS OF TRADE (TOT) ON SOME AGRICULTURAL INDICATORS IN IRAQ FOR THE PERIOD (1990 - 2019)

The Iraqi Journal of Agricultural science
This study aimed to investigate the impact of agricultural TOT shocks and the strength of their effects on some indicators of the agricultural sector. The research uses VAR, Variance decomposition and IRF approaches.
AlAttabi, H. A., B. H. AlBadri
doaj   +1 more source

Effect of High-k Oxide on Double Gate Transistor Embedded in RF Colpitts Oscillator [PDF]

Журнал нано- та електронної фізики, 2016
The Linear Time Variant (LTV) model of phase noise is considered. It is based on the Impulse Sensitivity Function (ISF) which describes carefully the sensitivity of an oscillator to a parasite impulse current injection in different nodes of the circuit.
M. Bella, S. Latreche, C. Gontrand
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source