Results 31 to 40 of about 64,993 (239)

Aerodynamic Admittance Function using Impulse Response Function Approach

International Journal of Advances in Scientific Research and Engineering, 2018
An explanation described here is how the aerodynamic admittance function(AAF) is to derive by means of impulse response function(IMF) which is modified for two peaks (movement-induced and Karman Vortex-induced) intending to be able to deal with the response condition under higher reduced wind speed.
May Thu Thu Htun, Khin Aye Mon
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Modelling of Green function in a rectangular room based upon the geometrical-filtration model

Archives of Acoustics, 2014
Significant problem in room acoustic is evaluating an acoustic quality of projected and modernized rooms. Estimation of room impulse response giving posibility to evaluate the subjective and objective room acoustic properties and hence to run the room ...
R. Marczuk, L. Majkut
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Critical response of a single-degree-of-freedom system with bilinear hysteresis and viscous damping under triple impulse

Frontiers in Built Environment
A triple impulse is used as a mathematical model of forward-directivity inputs, which are fault-normal components of near-fault earthquake ground motions. In this paper, two types of the triple impulse input are employed.
Kotaro Kojima, Izuru Takewaki
doaj   +1 more source

Critical earthquake response of a SDOF elastic‐perfectly plastic model with viscous damping under double impulse as a substitute for near‐fault ground motion

Japan Architectural Review, 2018
The double‐impulse input is introduced as a substitute for the fling‐step near‐fault ground motion, and a closed‐form solution for the approximate elastic‐plastic response of a structure with viscous damping under the “critical double impulse” is derived.
Kotaro Kojima, Yoshito Saotome, Izuru Takewaki   +2 more
doaj   +1 more source

Basis Functions for a Transient Analysis of Linear Commensurate Fractional-Order Systems

Algorithms, 2023
In this paper, the possibilities of expressing the natural response of a linear commensurate fractional-order system (FOS) as a linear combination of basis functions are analyzed.
Dalibor Biolek, Viera Biolková, Zdeněk Kolka, Zdeněk Biolek   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source