Results 41 to 50 of about 64,993 (239)

A joint impulse response function for vector autoregressive models

Empirical Economics, 2020
AbstractMany applications call for measuring the response due to shocks from several variables at once. We introduce a joint impulse response function (jIRF) that is independent of the order of the variables and allows for simultaneous shocks from multiple variables in the VAR, rather than one at a time as in the generalized IRF.
Thomas F. P. Wiesen, Paul M. Beaumont
openaire   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

EFFECT OF SHOCKS OF AGRICULTURAL TERMS OF TRADE (TOT) ON SOME AGRICULTURAL INDICATORS IN IRAQ FOR THE PERIOD (1990 - 2019)

The Iraqi Journal of Agricultural science
This study aimed to investigate the impact of agricultural TOT shocks and the strength of their effects on some indicators of the agricultural sector. The research uses VAR, Variance decomposition and IRF approaches.
AlAttabi, H. A., B. H. AlBadri
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Surrogate impulse ground motion for practical simulation of critical nonlinear structural responses

Frontiers in Built Environment
Impulse-based representations of earthquake ground motions provide an efficient framework for evaluating critical nonlinear structural responses. However, the direct use of ideal impulse ground motions expressed by Dirac’s delta function may excite all ...
Hiroki Akehashi, Mao Kinoshita, Fumiya Ueno, Koji Yamato, Yusuke Ehara, Tatsuhiko Maeda   +5 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

On the Volatility Spillover between Agricultural Commodities and Latin American Stock Markets

Risks, 2018
Addressing the volatility spillovers of agricultural commodities is important for at least two reasons. First, for the last several years, the volatility of agricultural commodity prices seems to have increased.
Vincenzo Candila, Salvatore Farace
doaj   +1 more source

Effect of High-k Oxide on Double Gate Transistor Embedded in RF Colpitts Oscillator [PDF]

Журнал нано- та електронної фізики, 2016
The Linear Time Variant (LTV) model of phase noise is considered. It is based on the Impulse Sensitivity Function (ISF) which describes carefully the sensitivity of an oscillator to a parasite impulse current injection in different nodes of the circuit.
M. Bella, S. Latreche, C. Gontrand
doaj   +1 more source

On the Integration Schemes of Retrieving Impulse Response Functions from Transfer Functions [PDF]

Mathematical Problems in Engineering, 2010
The numerical inverse Laplace transformation (NILM) makes use of numerical integration. Generally, a high‐order scheme of numerical integration renders high accuracy. However, surprisingly, this is not true for the NILM to the transfer function.
Chen, Kui Fu, Li, Yan Feng
openaire   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source