Results 41 to 50 of about 415,160 (303)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Critical earthquake response of a SDOF elastic‐perfectly plastic model with viscous damping under double impulse as a substitute for near‐fault ground motion

Japan Architectural Review, 2018
The double‐impulse input is introduced as a substitute for the fling‐step near‐fault ground motion, and a closed‐form solution for the approximate elastic‐plastic response of a structure with viscous damping under the “critical double impulse” is derived.
Kotaro Kojima, Yoshito Saotome, Izuru Takewaki   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Modelling of Green function in a rectangular room based upon the geometrical-filtration model

Archives of Acoustics, 2014
Significant problem in room acoustic is evaluating an acoustic quality of projected and modernized rooms. Estimation of room impulse response giving posibility to evaluate the subjective and objective room acoustic properties and hence to run the room ...
R. Marczuk, L. Majkut
doaj  

Double-sampled cascaded sigma-delta modulator topologies for low oversampling ratios [PDF]

, 2006
This paper presents novel double-sampling cascaded sigma-delta modulator topologies for wideband applications. The proposed modulator structures employ finite impulse response (FIR) noise transfer function (NTF) to achieve the aggressive noise shaping ...
Rodríguez Vázquez, Ángel Benito, Shoaei, Omid, Yavari, Mohammad   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Basis Functions for a Transient Analysis of Linear Commensurate Fractional-Order Systems

Algorithms, 2023
In this paper, the possibilities of expressing the natural response of a linear commensurate fractional-order system (FOS) as a linear combination of basis functions are analyzed.
Dalibor Biolek, Viera Biolková, Zdeněk Kolka, Zdeněk Biolek   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Critical response of a single-degree-of-freedom system with bilinear hysteresis and viscous damping under triple impulse

Frontiers in Built Environment
A triple impulse is used as a mathematical model of forward-directivity inputs, which are fault-normal components of near-fault earthquake ground motions. In this paper, two types of the triple impulse input are employed.
Kotaro Kojima, Izuru Takewaki
doaj   +1 more source

The temporal impulse response function during smooth pursuit

Vision Research, 2009
Recent studies indicate that the extent of perceived motion smear is attenuated asymmetrically during smooth pursuit eye movements, based on the relative directions of the target and eye motion. We conducted two experiments to determine if the reduction of perceived smear during pursuit might be associated with an acceleration of the temporal impulse ...
Tong, Jianliang, Ramamurthy, Mahalakshmi, Patel, Saumil S., Vu-Yu, Lan-Phuong, Bedell, Harold E.   +4 more
openaire   +2 more sources