Results 31 to 40 of about 131,401 (219)

New-Generation Ferroelectric AlScN Materials

Nano-Micro Letters
Highlights Ferroelectricity and domain dynamics of emerging ferroelectric AlScN films were discussed. The performance optimization of ferroelectric AlScN films grown by different deposition techniques was comprehensively analyzed.
Yalong Zhang, Qiuxiang Zhu, Bobo Tian, Chungang Duan   +3 more
doaj   +1 more source

Fast and Reconfigurable Logic Synthesis in Memristor Crossbar Array

Advanced Intelligent Systems, 2022
Memristor is a potential basic unit for the in‐memory computing system, which is an approach to break the memory wall of the traditional computer. However, low switching speed, nonuniform device characteristics, and inefficient logic synthesis hinder the
Wei Wang, Sen Liu, Qingjiang Li, Tuo Shi, Feng Zhang, Haijun Liu, Nan Li, Yongzhou Wang, Yi Sun, Bing Song, Hui Xu, Qi Liu   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Hardware Implementation of Next Generation Reservoir Computing with RRAM‐Based Hybrid Digital‐Analog System

Advanced Intelligent Systems
Reservoir computing (RC) possesses a simple architecture and high energy efficiency for time‐series data analysis through machine learning algorithms. To date, RC has evolved into several innovative variants. The next generation reservoir computing (NGRC)
Danian Dong, Woyu Zhang, Yuanlu Xie, Jinshan Yue, Kuan Ren, Hongjian Huang, Xu Zheng, Wen Xuan Sun, Jin Ru Lai, Shaoyang Fan, Hongzhou Wang, Zhaoan Yu, Zhihong Yao, Xiaoxin Xu, Dashan Shang, Ming Liu   +15 more
doaj   +1 more source

A Tiki-Taka-Inspired SOT-MRAM In-Memory Computing Architecture for Long-Term Edge Learning

Applied Sciences
Spin–Orbit Torque Magnetic Random-Access Memory (SOT-MRAM)-based in-memory computing (IMC) offers a transformative solution for energy-efficient edge intelligence, yet the deployment of robust online learning remains challenging due to memristive non ...
Yu Li, Fengjun Dong, Guozhong Xing
doaj   +1 more source