Results 41 to 50 of about 131,401 (219)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Convolutional Echo‐State Network with Random Memristors for Spatiotemporal Signal Classification

Advanced Intelligent Systems, 2022
The unprecedented development of Internet of Things results in the explosion of spatiotemporal signals generated by smart edge devices, leading to a surge of interest in real‐time learning of such data.
Shaocong Wang, Hegan Chen, Woyu Zhang, Yi Li, Dingchen Wang, Shuhui Shi, Yaping Zhao, Kam Chi Loong, Xi Chen, Yujiao Dong, Yi Zhang, Yang Jiang, Chaudhry Furqan, Jia Chen, Qing Wang, Xiaoxin Xu, Guangyi Wang, Hongyu Yu, Dashan Shang, Zhongrui Wang   +19 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Quantum-enhanced reconfigurable in-memory stochastic computing

Light: Science & Applications
In-memory computing, which enables computation directly within memory, represents an efficient approach to processing massively parallel computation tasks that are intractable for conventional computers.
Hong-Zhe Yang, Jian-Peng Dou, Feng Lu, Xiao-Wen Shang, Chao-Ni Zhang, Heng Zhou, Hao Tang, Xian-Min Jin   +7 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Advanced Integration-Inspired Process-in-Memory: A Comprehensive Review of Design, Challenges, and Future Prospects

IEEE Access
This work provides a comprehensive overview of advanced integration-inspired memory process design, focusing on the integration methods of 2D, 2.5D, and 3D.
Jinhui Cheng, Zhaoliang Guan, Jiangduo Fu, Hangyu Xu, Jinkun Ke   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Profound Leadership Strategies: Transcending the Leadership Crisis in the Age of Artificial Intelligence

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley   +1 more source

In Situ Quantization with Memory‐Transistor Transfer Unit Based on Electrochemical Random‐Access Memory for Edge Applications

Advanced Science
In‐memory computing based on nonvolatile synaptic arrays with computing functions has significantly improved the computing energy efficiency of neural networks.
Zhen Yang, Yuxiang Yang, Baiqian Wang, Yaoyu Tao, Zelun Pan, Lei Cai, Teng Zhang, Longhao Yan, Xianbin Li, Yuchao Yang   +9 more
doaj   +1 more source