Results 151 to 160 of about 115,317,412 (280)

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun, Marie Hofmann, Rebecca Rancourt, Julia Sommer, Alexandra Kühn, Loreen Ehrlich, Thomas Ziska, Kerstin Melchior, Karen Schellong, Wolfgang Henrich, Sonja Entringer, Katherine Margaret Kennedy, Andreas Plagemann, Deborah Magdalena Sloboda   +13 more
wiley   +1 more source

Decoding sequence recognition code of nucleic acid‐binding proteins of human‐infecting DNA viruses

iMeta, EarlyView.
Human‐infecting DNA viruses remain major health threats, yet the DNA‐recognition mechanisms of their nucleic acid‐binding proteins (NBPs) are poorly understood. Here, we systematically profiled 103 viral NBPs from human‐infecting DNA viruses, with three NBPs from non‐human‐infecting DNA viruses as controls, using high‐throughput screening.
Meifang Tang, Shifei Yang, Haiqian Ma, Ruoying Guo, Jie Chen, Hui Zhang, Jinghan Zhang, Wei Sun, Yun Wei, Ligang Fan, Jian Yan   +10 more
wiley   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Transvaginal Strain Elastography Methodology in Deep Endometriosis

Journal of Ultrasound in Medicine, EarlyView.
Objectives Transvaginal strain elastography (SE) has emerged as a complementary technique to transvaginal ultrasound for deep endometriosis (DE) evaluation by exploiting tissue stiffness between lesions and surrounding structures. However, its clinical adoption remains limited by marked methodological heterogeneity across studies.
Ana Claudia Brunelli Tosato, Flávia Moro Ferrari, Cristiane Martins de Almeida, Rodrigo Menezes Jales, Cristina Laguna Benetti‐Pinto   +4 more
wiley   +1 more source

Intrinsically Design‐Rule‐Compliant Nanophotonic Inverse Design via Learned Generative Manifolds

Laser &Photonics Reviews, EarlyView.
A generative reparameterization framework for nanophotonic inverse design is introduced, restricting optimization to a learned manifold of design‐rule‐compliant geometries. Unlike conventional penalty‐based approaches, fabrication constraints are encoded intrinsically within the design representation.
Bahrem Serhat Danis, Demet Baldan Desdemir, Enes Akcakoca, Zeynep Ipek Yanmaz, Gulzade Polat, Ahmet Onur Dasdemir, Aytug Aydogan, Abdullah Magden, Emir Salih Magden   +8 more
wiley   +1 more source

Design, Synthesis and Biophysical Characterisation of CPP-PNA Conjugates for Targeting Oncogenic microRNA-221. [PDF]

J Pept Sci
Cell‐penetrating peptide‐peptide nucleic acid (CPP‐PNA) conjugates that target the oncogenic microRNA‐221‐5p were synthesised using Cu(I)‐catalysed azide‐alkyne cycloaddition (CuAAC) and disulfide‐mediated conjugation strategies. These constructs form highly stable, sequence‐selective PNA/RNA heteroduplexes and demonstrate preliminary antiproliferative
Rotondo M, Illien F, Burlina F, Biondi B.   +3 more
europepmc   +2 more sources

Analysis of Corrosion and Wall Perforation in the Heat Exchanger Made of AISI 316L Stainless Steel

Materials and Corrosion, EarlyView.
Elevated passivation temperature is identified as the dominant factor triggering localized corrosion and subsequent perforation of AISI 316L heat exchanger tubes. Electrochemical and complementary characterization results show that the alloy retains high resistance to general, pitting, and intergranular corrosion, indicating that failure primarily ...
Bojana Radojković, Bore Jegdić, Branimir Grgur, Stefan Dikić, Jovanka Pejić, Anđela Simović, Nataša Gajić, Aleksandra Popović   +7 more
wiley   +1 more source

Circularly Co-Polarized Full-Duplex Horn Antenna with Twisted Dielectric Polarizer

A novel conical horn antenna for full-duplex wireless communication with a dielectric polarizing insert and a flare-angle change is presented. Both orthogonal linear polarizations of the circular waveguide feed, caring transmitter and receiver signals ...
Budimir, D., Jankovic, U.
core   +1 more source