Decoding sequence recognition code of nucleic acid‐binding proteins of human‐infecting DNA viruses
iMeta, EarlyView.Human‐infecting DNA viruses remain major health threats, yet the DNA‐recognition mechanisms of their nucleic acid‐binding proteins (NBPs) are poorly understood. Here, we systematically profiled 103 viral NBPs from human‐infecting DNA viruses, with three NBPs from non‐human‐infecting DNA viruses as controls, using high‐throughput screening.
Meifang Tang +10 more
wiley +1 more source
Nonlinear Digital Self-Interference Cancellation in In-Band Full-Duplex Systems with Complex-Valued Temporal Convolution. [PDF]
Sensors (Basel)Chen J, Wang X, Wang R, Zhao H.
europepmc +1 more source
Deciphering transcriptome complexity via long‐read sequencing
iMeta, EarlyView.Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu +21 more
wiley +1 more source
Digital Self-Interference Cancellation Strategies for In-Band Full-Duplex: Methods and Comparisons. [PDF]
Sensors (Basel)Shahghasi A, Montoro G, Gilabert PL.
europepmc +1 more source
iNew Medicine, EarlyView.A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu +11 more
wiley +1 more source
A low-complexity compact dual-polarized patch antenna with high isolation and low cross-polarization for in-band full-duplex applications. [PDF]
Sci RepTran-Huy H +6 more
europepmc +1 more source
Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
Transvaginal Strain Elastography Methodology in Deep Endometriosis
Journal of Ultrasound in Medicine, EarlyView.Objectives Transvaginal strain elastography (SE) has emerged as a complementary technique to transvaginal ultrasound for deep endometriosis (DE) evaluation by exploiting tissue stiffness between lesions and surrounding structures. However, its clinical adoption remains limited by marked methodological heterogeneity across studies.
Ana Claudia Brunelli Tosato +4 more
wiley +1 more source
Intrinsically Design‐Rule‐Compliant Nanophotonic Inverse Design via Learned Generative Manifolds
Laser &Photonics Reviews, EarlyView.A generative reparameterization framework for nanophotonic inverse design is introduced, restricting optimization to a learned manifold of design‐rule‐compliant geometries. Unlike conventional penalty‐based approaches, fabrication constraints are encoded intrinsically within the design representation.
Bahrem Serhat Danis +8 more
wiley +1 more source
Design, Synthesis and Biophysical Characterisation of CPP-PNA Conjugates for Targeting Oncogenic microRNA-221. [PDF]
J Pept SciCell‐penetrating peptide‐peptide nucleic acid (CPP‐PNA) conjugates that target the oncogenic microRNA‐221‐5p were synthesised using Cu(I)‐catalysed azide‐alkyne cycloaddition (CuAAC) and disulfide‐mediated conjugation strategies. These constructs form highly stable, sequence‐selective PNA/RNA heteroduplexes and demonstrate preliminary antiproliferative
Rotondo M +3 more
europepmc +2 more sources