Results 221 to 230 of about 115,317,412 (279)

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Development and internal validation of a new Varicose Vein Recurrence Score for open superficial venous surgery. [PDF]

J Vasc Surg Venous Lymphat Disord
Nikolić D, Petrović K, Manojlović V, Budinski S, Batinić N, Basta Nikolić M.   +5 more
europepmc   +1 more source

Unraveling G-Quadruplex and i-Motif Coexistence Within a Double-Stranded DNA. [PDF]

Angew Chem Int Ed Engl
Auricchio D, Ghezzo M, Zavrtanik U, Bertini L, Libera V, Rigo R, Lah J, Sissi C.   +7 more
europepmc   +1 more source

A rapid visual detection method for indel polymorphisms in the bovine PRNP gene based on a duplex MIRA-LFD assay. [PDF]

Front Vet Sci
Xu Y, Yang S, Ding S, Xu T, Zhu L, Xiao W, Ge J, Guan F.   +7 more
europepmc   +1 more source

Coupling Exponential Rolling Circle Amplification to Lateral Flow Devices for Point‐of‐Care Detection of Viral RNA

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A new exponential RCA (E‐RCA) system was developed and coupled to a toehold system for release of a bridging DNA, allowing for lateral flow detection. The E‐RCA method uses a secondary primer (P2) that binds RCA products (RCAP) to generate extended P2 products that can re‐prime a partially self‐complementary circular template, generating a complete ...
Amal Mathai, Monsur Ali, Yingfu Li, John D. Brennan   +3 more
wiley   +1 more source

Synthesis of functionalized, 13-alkyl-substituted coralyne derivatives and investigation of their interactions with duplex and abasic site-containing DNA. [PDF]

Beilstein J Org Chem
Beckmann L, Kunze JL, Strunk HK, Michel M, Ihmels H.   +4 more
europepmc   +1 more source

Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma, Erika McCarthy, N. Sanjeeva Murthy, Cameron McGovern, Zhenyu Han, Şölen Ekesan, Subhajit Nandi, Advik Sirimarapu, Wilma K. Olson, Darrin M. York, Yuwei Gu   +10 more
wiley   +1 more source

Biocompatible fluorescent carbon dot-based nanoprobes for G-quadruplex targeting in cancer cells.

Mater Adv
García-Millán T, Hunt E, Allen NM, Giorio GAM, Oliver TAA, Ramos-Soriano J, Galan MC.   +6 more
europepmc   +1 more source

SARS-CoV-2 Nsp13 helicase resolves G-quadruplexes and is inhibited by G4 ligands or an antiviral regulator: Implications for G4 anti-coronavirus therapies. [PDF]

J Biol Chem
George JC, Kulikowicz T, Bombard PT, Rossi M, Dumm AJ, Anderson OM, Sommers JA, Brosh RM.   +7 more
europepmc   +1 more source