Results 41 to 50 of about 118,482,436 (243)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Data for: Stress-State Differences between Sedimentary Cover and Basement of the Songliao Basin, NE China: In-situ Stress Measurements at 6-7 km depth of an ICDP Scientific Drilling Borehole (SK-II)

, 2021
The original data of ASR in-situ stress measurement ...
sun, donsheng
core   +1 more source

Research on In Situ Stress Measurement Based on the Combined Method of DIC and Drilling Stress Relief

Buildings
Existing structural stress is an important parameter for evaluating the current state of a structure. In order to improve the accuracy of in situ stress measurement in the field, this paper proposes an in situ stress measurement method for existing ...
Lingting Ye, Liping Chen, Peng Zhao, Ruichuan Zhao, Yixiang Zhou   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

In-situ measurements of mechanical property and stress evolution of commercial graphite electrode

Materials & Design, 2020
Li ion concentration-dependent mechanical properties and stress of electrodes are crucial to the performance and durability of lithium-ion batteries.
Dawei Li, Yikai Wang
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Measurements Of In Situ Stress And Mining-Induced Stress In Beiminghe Iron Mine Of China

, 2009
In order to obtain the distribution rules of in situ stress and mining-induced stress of Beiminghe Iron Mine, the stress relief method by overcoring was used to measure the in situ stress, and the MC type bore-hole stress gauge was adopted to measure the
Xu WC, Li CH, Li HJ, Ouyang ZH, 欧阳振华   +4 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Evaluating the Core-Based Stress Measurement in Mining Engineering—A Critical Review of the Diametrical Core Deformation Technique

Applied Sciences
Accurate determination of in situ stress is fundamental for the safe and efficient design of underground construction projects such as tunnels, caverns, and deep mining excavations. Conventional techniques—particularly overcoring and hydraulic fracturing—
Yizhuo Li, Baokun Zhou, Hani S. Mitri, Anlin Shao   +3 more
doaj   +1 more source

Research on the correction method of hydraulic fracturing in-situ stress testing based on MLP-KFold [PDF]

Geoscientific Instrumentation, Methods and Data Systems
Hydraulic fracturing serves as a critical in-situ stress testing technique, where the accurate determination of rock fracture pressure and closure pressure in fracturing intervals is essential for precise in-situ stress estimation.
Y. Liu, J. Zhou, H. Chen, J. Luo, J. Luo
doaj   +1 more source