Results 41 to 50 of about 114,713,249 (284)

In Situ Stress Inversion in a Pumped-Storage Power Station Based on the PSO-SVR Algorithm

Applied Sciences
An accurate in situ stress field is a prerequisite for evaluating the stability of surrounding rock in underground caverns of a pumped-storage power station (PSPS) and ensuring the long-term safe operation of underground powerhouses.
Lu Liu, Jinhui Ouyang, Genqian Nian, Youping Zhu, Ning Liang   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In-Situ

Formed in 2012, In-Situ is an artist led not-for-profit arts organisation based in Brierfield, Pendle, Lancashire. In-Situ openly explores the built and natural environment; how we live our lives; perceptions of the everyday, shared histories; and local
Morrison, Kerry, Titley, William David, Hartley, Paul   +2 more
core   +6 more sources

Major advances and prospects in in-situ stress measurement and estimation methods over the past 10 years (2014–2025）

Dizhi lixue xuebao
Objective  The characteristics of the in-situ stress field are fundamental to major strategic underground engineering projects, deep earth resource and energy development, and geohazard prevention and control.
WANG Chenghu, LI Wei
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Research on In Situ Stress Measurement Based on the Combined Method of DIC and Drilling Stress Relief

Buildings
Existing structural stress is an important parameter for evaluating the current state of a structure. In order to improve the accuracy of in situ stress measurement in the field, this paper proposes an in situ stress measurement method for existing ...
Lingting Ye, Liping Chen, Peng Zhao, Ruichuan Zhao, Yixiang Zhou   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Archeologische begeleiding plangebied Poeldonk te Den Dungen, Gemeente Sint-Michielsgestel

, 2021
In 2018 en 2019 heeft Ex-Situ Archeologie een archeologische begeleiding uitgevoerd volgens het protocol proefsleuven en/of opgraving in het plangebied Poeldonk te Den Dungen in de gemeente Sint- Michielsgestel.
Hoegen, drs R.D. (Ex-Situ Archeologie B.V.)
core   +1 more source