Results 51 to 60 of about 118,482,436 (243)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Features and mechanism of coseismic surface ruptures by Wenchuan earthquake of May 12, 2008

, 2010
The 5th International Symposium on In-Situ Rock Stress (ISRS-V), Beijing, China, 25-27 August 2010. In Rock Stress and Earthquake: proceedings of the 5th International Symposium on In-Situ Rock Stress, 2010, Chapter 124, p.
Z Yue, Yue, QZQ
core   +1 more source

Exploration and application of in-situ stress estimation method based on core disking phenomenon of boreholes

Dizhi lixue xuebao
Objective  Rock core disking is a typical phenomenon that occurs in environments with high in-situ stress. The geometric characteristics and section shape of rock disking are related to the state of in-situ stress, and the site where this phenomenon ...
YAN Shaokun, WANG Chenghu, GAO Guiyun, LIU Jikun, DAI Xiangqian   +4 more
doaj   +1 more source

In Situ Stress Prediction in Subsurface Rocks: An Overview and a New Method

Geofluids, 2021
Methods for determining in situ stresses are reviewed, and a new approach is proposed for a better prediction of the in situ stresses. For theoretically calculating horizontal stresses, horizontal strains are needed; however, these strains are very ...
Yushuai Zhang, Shangxian Yin, Jincai Zhang   +2 more
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

In-situ stress conditions at ODP Site 131-808

, 1993
Shipboard laboratory index property data, shore-based consolidation tests, and in-situ stress and pore-pressure measurements are used in this study to constrain the stress conditions at ODP Site 808, Nankai Trough.
Feeser, Volker, Kate Moran (6964625), R G Campanella (7979444), Volker Feeser (7979435), Warner Brückmann (467316), Campanella, R G, Brückmann, Warner, Moran, Kate   +7 more
core   +1 more source

Methods for in-situ stress measurements in rock mass [PDF]

, 2018
The stress in rock mass are essential for the stability of underground structures. Several methods for stress and strains measuring are known, around the world.
Doneva, Nikolinka, Hadzi-Nikolova, Marija, Adjiski, Vancho, Mijalkovski, Stojance   +3 more
core   +1 more source

Study on the Method for Measuring Stress on Rock Mass Excavation Surface under Extremely High Stress Conditions

Geofluids, 2022
In view of the limitations of several existing stress measurement methods under extremely high stress conditions (stress−strength ratio σ/Rc>0.5), this paper proposes a slot relief method based on partial deformation recovery to measure rock mass surface
Kai Ai, Xinhui Zhang, Chao Zhou
doaj   +1 more source

Inverse Identification of Energy‐Dependent Laser Absorptivity in NiTi Laser Powder‐Bed Fusion via Calibrated Melt Pool Simulation

Advanced Engineering Materials, EarlyView.
A combined experimental–computational framework identifies energy‐dependent laser absorptivity for NiTi in laser powder‐bed fusion, applicable to conduction and transition modes. Single‐track experiments and thermofluid smoothed particle hydrodynamics simulations are coupled through inverse analysis of melt pool geometry.
Mohamadreza Afrasiabi, Hadi Moutablaleh, Ignatius A. Setiawan, Mehrshad Mehrpouya   +3 more
wiley   +1 more source

Study of Pbtio₂ Formation Kinetics by an In-Situ Stress Measurement Technique

, 1993
The primary objective of this study is to demonstrate an in–situ stress measurement technique for the study of formation kinetics of multicomponent thin films such as PbTiO3.
Seshu B. Desu, Chen C. Li
core   +1 more source