Results 81 to 90 of about 620,275 (284)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail

Scientific Reports, 2017
Blood flow influences atherosclerosis by generating wall shear stress, which alters endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a process termed endothelial-to-mesenchymal transition (EndMT).
Marwa M. Mahmoud, Jovana Serbanovic-Canic, Shuang Feng, Celine Souilhol, Rouyu Xing, Sarah Hsiao, Akiko Mammoto, Jing Chen, Markus Ariaans, Sheila E. Francis, Kim Van der Heiden, Victoria Ridger, Paul C. Evans   +12 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Kernel methods for in silico chemogenomics

, 2007
Predicting interactions between small molecules and proteins is a crucial ingredient of the drug discovery process. In particular, accurate predictive models are increasingly used to preselect potential lead compounds from large molecule databases, or to
Jacob, Laurent, Vert, Jean-Philippe
core   +1 more source

Ratiometric control for differentiation of cell populations endowed with synthetic toggle switches

, 2019
We consider the problem of regulating by means of external control inputs the ratio of two cell populations. Specifically, we assume that these two cellular populations are composed of cells belonging to the same strain which embeds some bistable memory ...
di Bernardo, Mario, Fiore, Davide, Salzano, Davide   +2 more
core   +1 more source

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing [PDF]

, 2010
Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the ...
Aaron R. Jex, Altschul, Anja Joachim, Ashburner, Bentley, Bethony, Björnberg, Blaxter, Boag, Bronwyn E. Campbell, Caffrey, Campbell, Cantacessi, Cantacessi, Cantacessi, Cantacessi, Chan, Chang, Cinzia Cantacessi, Clifton, Conesa, Cottee, Cottee, Datu, DeRisi, Doyle, Flicek, Freigofas, Gasser, Golden, Greene, Gupta, Hawdon, Hopkins, Hotez, Hu, Huang, Hunter, Iseli, Jackson, Joachim, Joachim, Keil, Krasky, Letunic, Li, Li, Li, Lipinski, Makedonka Mitreva, Margulies, Matthew J. Nolan, McKay, Metzker, Miller, Miller, Mizuarai, Moreno, Morozova, Moser, Mufson, Mulvenna, Nagaraj, Nagaraj, Neil D. Young, Nikolaou, Nisbet, Olson, Parkinson, Paul W. Sternberg, Pong, Portman, Ranganathan, Ren, Robertson, Robin B. Gasser, Robinson, Ross S. Hall, Sahar Abubucker, Sanger, Sanger, Santos, Shoba Ranganathan, Soderlund, Stathopoulos, Stockdale, Tanaka, Vibranovski, Wang, Williamson, Wilson, Wu, Young, Young, Zhan, Zhong   +95 more
core   +5 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A longitudinal MRI dataset of brain metastases with tumor segmentations, clinical & radiomic data

Scientific Data
Brain metastases (BM) are a severe complication of multiple primary malignancies and constitute the most frequent tumors of the central nervous system.
Dimitra Flouri, Christos-Panagiotis Papanikas, Georgios C. Manikis, Eleftherios Ioannou, Georgia Karaoli, Elisavet Papageorgiou, Anastasia Constantinidou, Loizos Siakallis, Marilena Theodorou, Vasileios Vavourakis   +9 more
doaj   +1 more source