Results 111 to 120 of about 115,710,970 (297)

Designing novel solenoid proteins with in silico evolution

Communications Chemistry
Abstract Solenoid proteins are elongated tandem repeat proteins with diverse biological functions, making them attractive targets for protein design. Advances in machine learning have transformed our understanding of sequence-structure relationships, enabling new approaches for de novo protein design.
Daniella Pretorius, Georgi I. Nikov, Kono Washio, Steve-William Florent, Henry N. Taunt, Sergey Ovchinnikov, James W. Murray   +6 more
openaire   +2 more sources

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Proceedings of Formal Methods in Computer Aided Design, FMCAD 2018 [PDF]

, 2018
October 30 – November 2, 2018 in Austin, Texas, USATable of Contents: INVITED PAPERS -- Formal Verification of Deep Neural Networks / by Nina Narodytska (p. 1) -- Formal Verification of Unsatisfiability Results / by Marijn Heule (p.
Formal Methods in Computer Aided Design
core  

in-silico-uce-probes-to-contigs.lastz.tar.gz

, 2014
LASTZ files showing mapping of UCE probes onto in silico genome slices AND probe.matches.sqlite ...
Brant C. Faircloth (143432), Michael G. Branstetter (609954), White, Noor D., Faircloth, Brant C., Noor D. White (3248478), Brady, Séan G., Séan G. Brady (3248475), Branstetter, Michael G.   +7 more
core   +1 more source

Multi-epitope vaccine design against leishmaniasis using IFN-γ inducing epitopes from immunodominant gp46 and gp63 proteins

Journal of Genetic Engineering and Biotechnology
There is no currently approved human vaccine against leishmaniasis. Utilization of immunogenic antigens and their epitopes capable of enhancing immune responses against leishmaniasis is a crucial step for rational in silico vaccine design.
Amir Dehghani, Mina Mamizadeh, Atena Karimi, Seyyed Amir Hosseini, Davood Siamian, Morteza Shams, Shadan Ghiabi, Gholam Basati, Amir Abaszadeh   +8 more
doaj   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Journey of the GDS Program (2019-2022): Introduction, The Research Problem, Main Outcomes, Structure of the GDS Program in numbers, Timeline

, 2022
The GDS Program started in April 2019 and came to an end in October 2022. It was funded by the International Development Research Centre (IDRC) and was centrally managed and coordinated by Carleton University.
Gendered Design in STEAM
core   +1 more source

Ayurinformatics Laboratory- A synergy platform for Ayurveda and technology

Journal of Ayurveda and Integrative Medicine
The Ayush sector has attained buoyant growth in the past decade as a science, public health, medicine, and industry. Artificial Intelligence, computational drug designing, and other combinatorial techniques could further accelerate the sector's growth ...
Prashant Kumar Gupta, Tanuja Manoj Nesari   +1 more
doaj   +1 more source