Results 111 to 120 of about 169,844 (308)
MoleculesWhile natural products and derivatives have been crucial in drug discovery, the current databases are limited to known compounds. There is a need for tools that can automatically generate and assess novel derivatives of natural products to enhance early ...
Yu Song +4 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Journal of Genetic Engineering and BiotechnologyThere is no currently approved human vaccine against leishmaniasis. Utilization of immunogenic antigens and their epitopes capable of enhancing immune responses against leishmaniasis is a crucial step for rational in silico vaccine design.
Amir Dehghani +8 more
doaj +1 more source
Methods and applications of in silico aptamer design and modeling
, 2021 Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow the design of in vitro aptamers that bind particularly to a target
Buglak A.A.
core
Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
In-silico predictions of TKR robustness to wear variability: a probabilistic cross-design comparison
, 2009 Wear of TKR is a key concern for designers, but is highly variable in clinical retrievals. Conventional in-vitro knee wear simulators are limited to relatively small numbers of tests and cannot fully address this uncertainty; in-silico models can use ...
Taylor, Mark, Strickland, Michael A.
core
An in silico re-design of the metabolism in Thermotoga maritima for increased biohydrogen production
, 2012 peer reviewedMicrobial hydrogen production is currently hampered by lack of efficiency. We examine how hydrogen production in the hyperthermophilic bacterium Thermotoga maritima can be increased in silico.
THIELE, Ines +2 more
core +1 more source
In silico designed microporous carbons
Carbon, 2015 AbstractThis work presents a computational study on the packing of three-dimensional carbon nanostructures and their effect on gas adsorption properties. We show that it is possible to obtain intrinsically microporous materials without specifying structural properties such as surface area or pore size distribution by packing individual graphene ...
Gonciaruk, Aleksandra +1 more
openaire +2 more sources
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source