Results 41 to 50 of about 119,597,839 (255)

Characterization of natural therapeutic compounds producing novel bacterial strains isolated from Hyderabad, India

Scientific Reports
Natural products (NPs) are secondary metabolites that exert their biological effects within and on other organisms. Bacteria are considered potent producers of bioactive natural compounds, due to their versatile biocatalytic activity.
Anushka Bhrdwaj, Anuraj Nayarisseri, Sanjeev Kumar Singh   +2 more
doaj   +1 more source

Computational mapping of resistance-relevant signals in proteins using deep and classical feature spaces

Frontiers in Microbiology
IntroductionThe functional diversity of antimicrobial resistance (AMR) proteins necessitates advanced computational frameworks capable of capturing complex macromolecular signatures beyond simple sequence homology. While traditional alignment-based tools
Rahul Kaushik, Suyong Re
doaj   +1 more source

Les médicaments peptidiques : mythe ou réalité ? [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2008
Peptides as drugs: myth or reality? Peptides find many applications in the fields of biotechnology, among which pharmaceutical applications. Progression of the number of traditional drugs deposited at the FDA is slowing down. It’s the reason why many big
Brasseur R., Decaffmeyer M., Thomas A.
doaj  

in-silico-NOTES

, 2014
NOTES describing the pipeline steps used to analyze the in silico ...
Brant C. Faircloth (143432), Michael G. Branstetter (609954), Noor D. White (3248478), Séan G. Brady (3248475)   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Intrinsically disordered regions as drivers of protein aggregation: mechanisms, phase separation, and emerging predictive frameworks

Frontiers in Biophysics
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack stable tertiary structures yet perform essential roles in cellular signaling, molecular recognition, transcriptional regulation, and biomolecular assembly.
Rahul Kaushik, Suyong Re
doaj   +1 more source

hgcA-in-silico-primer-stats

, 2019
Results from in silico PCR of hgcA universal and clade specific primers with 0 and 2 mismatches run for each ...
Elizabeth McDaniel (7519667)
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

in-silico-RENAMED-TIPS.tree

, 2014
In silico tree with tips renamed to full species ...
Brant C. Faircloth (143432), Michael G. Branstetter (609954), White, Noor D., Faircloth, Brant C., Noor D. White (3248478), Brady, Séan G., Séan G. Brady (3248475), Branstetter, Michael G.   +7 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source