Results 31 to 40 of about 115,710,970 (297)

DNA module platform for developing colorimetric aptamer sensors

BioTechniques, 2016
Here we present a DNA module platform for developing simple aptamer sensors based on a microarray format combined with secondary structure prediction in silico.
Yasuyuki Tomita, Yuji Morita, Hiroaki Suga, Daisuke Fujiwara   +3 more
doaj   +1 more source

In-silico Design of Multi-epitope Vaccine against Nipah Virus using Immunoinformatics Approach

Journal of Pure and Applied Microbiology, 2021
Nipah virus is a pleomorphic virus that causes high mortality with unpredictable outbreaks. The virus also shows high zoonotic potential with long term neurological damage after recovery further adding to the disease burden.
Suraj Raju, Debasish Sahoo, Vikas Kumar Bhari   +2 more
doaj   +1 more source

In silico drug design [PDF]

Science-Business eXchange, 2013
A Dundee-UNC team has created a computational algorithm that mines medicinal chemistry literature to predict new ligands that bind specific combinations of GPCRs. Ex Scientia was spun out of Dundee to commercialize the technology.
openaire   +1 more source

In Silico Design of Robust Bolalipid Membranes [PDF]

Biomacromolecules, 2011
The robustness of microorganisms used in industrial fermentations is essential for the efficiency and yield of the production process. A viable tool to increase the robustness is through engineering of the cell membrane and especially by incorporating lipids from species that survive under harsh conditions.
Bulacu, Monica, Periole, Xavier, Marrink, Siewert J., Périole, Xavier   +3 more
openaire   +2 more sources

Artificial intelligence directed computational protein design: lessons from COVID-19 for pandemic-ready vaccines and antibody therapeutics

Journal of Pharmacy & Pharmaceutical Sciences
Artificial intelligence (AI) directed computational protein design has emerged as a transformative force in modern therapeutic discovery, reshaping how vaccines and antibody-based interventions are conceived, optimized, and deployed against emerging ...
Rahul Kaushik, Suyong Re
doaj   +1 more source

Computational mapping of resistance-relevant signals in proteins using deep and classical feature spaces

Frontiers in Microbiology
IntroductionThe functional diversity of antimicrobial resistance (AMR) proteins necessitates advanced computational frameworks capable of capturing complex macromolecular signatures beyond simple sequence homology. While traditional alignment-based tools
Rahul Kaushik, Suyong Re
doaj   +1 more source

Characterization of natural therapeutic compounds producing novel bacterial strains isolated from Hyderabad, India

Scientific Reports
Natural products (NPs) are secondary metabolites that exert their biological effects within and on other organisms. Bacteria are considered potent producers of bioactive natural compounds, due to their versatile biocatalytic activity.
Anushka Bhrdwaj, Anuraj Nayarisseri, Sanjeev Kumar Singh   +2 more
doaj   +1 more source

Intrinsically disordered regions as drivers of protein aggregation: mechanisms, phase separation, and emerging predictive frameworks

Frontiers in Biophysics
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack stable tertiary structures yet perform essential roles in cellular signaling, molecular recognition, transcriptional regulation, and biomolecular assembly.
Rahul Kaushik, Suyong Re
doaj   +1 more source

Les médicaments peptidiques : mythe ou réalité ? [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2008
Peptides as drugs: myth or reality? Peptides find many applications in the fields of biotechnology, among which pharmaceutical applications. Progression of the number of traditional drugs deposited at the FDA is slowing down. It’s the reason why many big
Brasseur R., Decaffmeyer M., Thomas A.
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source