Results 31 to 40 of about 169,844 (308)
DNA module platform for developing colorimetric aptamer sensors
BioTechniques, 2016 Here we present a DNA module platform for developing simple aptamer sensors based on a microarray format combined with secondary structure prediction in silico.
Yasuyuki Tomita +3 more
doaj +1 more source
, 2023 Drug discovery and repositioning are important processes for the pharmaceutical industry. These processes demand a high investment in resources and are time-consuming.
Alisson Silva +4 more
core +1 more source
Lib-INVENT: Reaction Based Generative Scaffold Decoration for in silico Library Design
, 2021 Due to the strong relationship between desired molecular activity to its structural core, screening of focused, core sharing chemical libraries is a key step in lead optimisation.
Jiaxi, Zhao +6 more
core +1 more source
Science-Business eXchange, 2013 A Dundee-UNC team has created a computational algorithm that mines medicinal chemistry literature to predict new ligands that bind specific combinations of GPCRs. Ex Scientia was spun out of Dundee to commercialize the technology.
openaire +1 more source
In Silico Design of Small RNA Switches [PDF]
IEEE Transactions on NanoBioscience, 2007 The discovery of natural RNA sensors that respond to a change in the environment by a conformational switch can be utilized for various biotechnological and nanobiotechnological advances. One class of RNA sensors is the riboswitch: an RNA genetic control element that is capable of sensing small molecules, responding to a deviation in ligand ...
Assaf, Avihoo +3 more
openaire +2 more sources
Les médicaments peptidiques : mythe ou réalité ? [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2008 Peptides as drugs: myth or reality? Peptides find many applications in the fields of biotechnology, among which pharmaceutical applications. Progression of the number of traditional drugs deposited at the FDA is slowing down. It’s the reason why many big
Brasseur R., Decaffmeyer M., Thomas A.
doaj
Journal of Pharmacy & Pharmaceutical SciencesArtificial intelligence (AI) directed computational protein design has emerged as a transformative force in modern therapeutic discovery, reshaping how vaccines and antibody-based interventions are conceived, optimized, and deployed against emerging ...
Rahul Kaushik, Suyong Re
doaj +1 more source
In Silico Design of Robust Bolalipid Membranes [PDF]
Biomacromolecules, 2011 The robustness of microorganisms used in industrial fermentations is essential for the efficiency and yield of the production process. A viable tool to increase the robustness is through engineering of the cell membrane and especially by incorporating lipids from species that survive under harsh conditions.
Bulacu, Monica +3 more
openaire +2 more sources
Molecules, 2022 Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is
Ashraf M. Muhammad +5 more
doaj +1 more source
In Silico Studies to Support Vaccine Development
, 2023 The progress that has been made in computer science positioned in silico studies as an important and well-recognized methodology in the drug discovery and development process.
Ülo Langel +5 more
core +1 more source