Results 11 to 20 of about 119,597,839 (255)
Mechanistic modeling for agroecological adaptation: genetic potential, uncertainty, and in silico design [PDF]
Frontiers in BioinformaticsBiological adaptation is increasingly studied through data-rich descriptions of environments, organisms, and their interactions. In crop systems, this challenge is especially concrete: genetic potential, physiological regulation, soil–water dynamics ...
Edgar S. Correa, Francisco C. Calderon
doaj +2 more sources
A Guide to In Silico Drug Design
Pharmaceutics, 2022 The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially available product, often due to factors, such as poor binding affinity, off-target effects, or ...
Yiqun Chang +5 more
doaj +2 more sources
In silico exploration of novel protease inhibitors against coronavirus 2019 (COVID-19)
Informatics in Medicine Unlocked, 2021 The spread of SARS-CoV-2 has affected human health globally. Hence, it is necessary to rapidly find the drug-candidates that can be used to treat the infection.
Elham Aghaee +2 more
doaj +1 more source
Development and validation of anti-human Alpha synuclein DNA aptamer using computer modelling techniques—an in silico study [PDF]
Journal of Integrative Neuroscience, 2022 Background: Biomarker detection strategies have, in recent years, been moving towards nucleic acid-based detection systems in the form of aptamers, short oligonucleotide sequences which have shown promise in pre-clinical and research settings.
Marcus Rock +7 more
doaj +1 more source
Research in Pharmaceutical Sciences, 2022 Background and purpose: The lack of a new effective treatment for small cell lung cancer (SCLC) is an unresolved problem. Due to the new identification of delta-like ligand 3 (DLL3) and its high expression in SCLC patients, the use of DLL3 in target ...
Mohammad Hossein Ataee +5 more
doaj +1 more source
Smart Approach for the Design of Highly Selective Aptamer-Based Biosensors
Biosensors, 2022 Aptamers are chemically synthesized single-stranded DNA or RNA oligonucleotides widely used nowadays in sensors and nanoscale devices as highly sensitive biorecognition elements. With proper design, aptamers are able to bind to a specific target molecule
Ali Douaki +8 more
doaj +1 more source
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery [PDF]
, 2020 Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of ...
Beekman, Andrew Michael +5 more
core +3 more sources
Saudi Pharmaceutical Journal, 2016 Mer receptor tyrosine kinase is a promising novel cancer therapeutic target in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.
Fereshteh Shiri +2 more
doaj +1 more source
JTCVS Open, 2020 Objectives: Right ventricle to pulmonary artery (RV-PA) conduits are required for the surgical management of pulmonary atresia with ventricular septal defect and truncus arteriosus.
Pegah Ebrahimi, MPhil +6 more
doaj +1 more source
Applied Sciences, 2020 Metabolic syndrome comprises a cluster of diseases like hypertension, dyslipidemia, and insulin resistance, among others. Its treatment is based on lifestyle modification; however, this treatment often fails to improve metabolic syndrome indicators over ...
Diego Armando Maldonado-Torres +4 more
doaj +1 more source