Results 11 to 20 of about 169,844 (308)
Smart Approach for the Design of Highly Selective Aptamer-Based Biosensors
Biosensors, 2022 Aptamers are chemically synthesized single-stranded DNA or RNA oligonucleotides widely used nowadays in sensors and nanoscale devices as highly sensitive biorecognition elements. With proper design, aptamers are able to bind to a specific target molecule
Ali Douaki +8 more
doaj +1 more source
In silico design of telomerase inhibitors
Drug Discovery Today, 2020 Telomerase is a reverse transcriptase enzyme involved in DNA synthesis at the end of linear chromosomes. Unlike in most other cells, telomerase is reactivated most cancerous cells and, therefore, has become a promising new anticancer target. Despite extensive research, direct telomerase inhibitors have yet not been introduced to the clinics because of ...
Maciej Baginski, Katarzyna Serbakowska
openaire +2 more sources
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery [PDF]
, 2020 Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of ...
Beekman, Andrew Michael +5 more
core +1 more source
JTCVS Open, 2020 Objectives: Right ventricle to pulmonary artery (RV-PA) conduits are required for the surgical management of pulmonary atresia with ventricular septal defect and truncus arteriosus.
Pegah Ebrahimi, MPhil +6 more
doaj +1 more source
Toxins, 2023 The escalating prevalence of antibiotic-resistant bacteria poses an immediate and grave threat to public health. Antimicrobial peptides (AMPs) have gained significant attention as a promising alternative to conventional antibiotics.
Min Kyoung Shin +8 more
doaj +1 more source
Design, in silico and pharmacological evaluation of a peptide inhibitor of BACE-1
Frontiers in Pharmacology, 2023 Introduction: Alzheimer’s disease (AD) is the main type of dementia, caused by the accumulation of amyloid plaques, formed by amyloid peptides after being processed from amyloid precursor protein (APP) by γ- and ß-secretases (BACE-1).
Renata Boldin +4 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2016 Mer receptor tyrosine kinase is a promising novel cancer therapeutic target in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.
Fereshteh Shiri +2 more
doaj +1 more source
Applied Sciences, 2020 Metabolic syndrome comprises a cluster of diseases like hypertension, dyslipidemia, and insulin resistance, among others. Its treatment is based on lifestyle modification; however, this treatment often fails to improve metabolic syndrome indicators over ...
Diego Armando Maldonado-Torres +4 more
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Toward in silico Catalyst Optimization
, 2022 In this minireview, we overview a computational pipeline that can be used to successfully reproduce the enantiomeric ratios of homogeneous catalytic reactions.
Nicolai, Cramer +4 more
core +1 more source
Journal of Experimental Life Science, 2022 Klebsiella pneumoniae is the main leading cause of hospital-acquired infection, leading to severe infections such as pneumonia and urinary tract infection.
Maulana Wildan Seputra +2 more
doaj +1 more source