Results 101 to 110 of about 93,106 (305)
Computational modeling and simulation in oncology
Clinical and Translational DiscoveryComputational modeling and simulation are playing an increasingly important role in oncology, bridging biological research, data science and clinical practice to better understand cancer complexity and inform therapeutic development.
Christian Baumgartner
doaj +2 more sources
HeliyonThe molecular chaperone heat shock proteins 70 (Hsp70) play a pivotal role in preserving cellular integrity and managing stress. This study extensively examined two Hsp70 proteins, On-Hsp70cBi, inducible, and On-Hsp70cBc, constitutively expressed, in ...
Geraldine B. Dayrit +3 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Establishing In-silico Credibility of Patient-Specific Finite-Element Model in a Virtual Cohort
The feasibility of transcatheter aortic valve implantation (TAVI) has been investigated by in-silico modeling to assist clinicians in the pre-operative planning of the device implantation.
Catalano C. +8 more
core +1 more source
, 2019 Cytochrome P450 enzymes (CYPs) of the equine CYP3A subfamily are predominantly involved in drug metabolism. In this study, genetic variants of the equine CYP3A94, CYP3A95, and CYP3A97 were identified and characterized using in silico modeling and in ...
Elli, S +6 more
core +1 more source
Application of Ibuprofen Sodium Dihydrate for Thermochemical Energy Storage
Advanced Functional Materials, EarlyView.Ibuprofen sodium dihydrate is introduced as a durable organic salt hydrate for low‐temperature thermochemical energy storage, operating within 60°C–110°C with high energy density. At the material level, it delivers ∼99.9% cycling efficiency over 150 cycles without deliquescence, enabled by a dual energy‐storage mechanism coupling dehydration and phase ...
Kavin Chakravarthy Thangaraj +10 more
wiley +1 more source
, 2009 The number of genome-scale metabolic models has been rising quickly in recent years, and the scope of their utilization encompasses a broad range of applications from metabolic engineering to biological discovery.
Karin Radrich +5 more
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International Journal of Secondary MetaboliteThe consumption of tea, derived from Camellia sinensis, ranks second globally after water. This research explores the anti-inflammatory properties of tea plant varieties from Assam, including TEEN ALI, TV-17, and TV-22, through a comprehensive approach ...
Hariram Natarajan, Nishanth Pitcham
doaj +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Size of cannula for extracorporeal CO2 removal therapies [PDF]
, 2015 Extracorporeal CO2 removal devices (ECCO2R) can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome.
Dauby, Pierre +4 more
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