Results 141 to 150 of about 114,431,160 (255)
Multiagent modeling of sequential multiunit japanese auctions
, 2018 Features of modeling of auctions are investigated from the point of view of simulation (multiagent) modeling. The characteristic of auctions as object of modeling is resulted.
Yalovets, A.L.
core
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
In silico modelling of tumour-induced angiogenesis
, 2014 Angiogenesis, the process by which new vessels form from existing ones, is a key event in the development of a large and malignant vascularised tumour. A rapid expansion in in vivo and in vitro angiogenesis research in recent years has led to increased knowledge about the processes underlying angiogenesis and to promising steps forward in the ...
openaire +2 more sources
Advanced Science, EarlyView.An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi +8 more
wiley +1 more source
SiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet
Advanced Science, EarlyView.SiDT1 encodes a GA3‐oxidase that creates a semi‐dwarf, lodging‐resistant architecture reminiscent of the rice Green Revolution. The resulting ideotype performs well under dense planting and provides a valuable genetic resource for high‐yield, mechanized foxtail millet production. ABSTRACT Foxtail millet (Setaria italica) is a drought‐tolerant C4 cereal
Jianzhen Lv +13 more
wiley +1 more source
Aging MedicinePurpose Premature cellular senescence is a pivotal process in aging and age‐related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with ...
Vinícius Pierdoná +6 more
doaj +1 more source
Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations
Advanced Science, EarlyView.Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford +3 more
wiley +1 more source
Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies [PDF]
Michelle Natasha Colin, Nur Shelly Ester Claudiana, Annisa Utami Kaffah, Aliya Nur Hasanah, Sandra Megantara Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, IndonesiaCorrespondence ...
Claudiana NSE +4 more
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Establishing In-silico Credibility of Patient-Specific Finite-Element Model in a Virtual Cohort
The feasibility of transcatheter aortic valve implantation (TAVI) has been investigated by in-silico modeling to assist clinicians in the pre-operative planning of the device implantation.
Catalano C. +8 more
core +1 more source
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source