Results 141 to 150 of about 93,106 (305)

Chemical Analysis and Biological Potential of Cotton Lavender Ethanolic Extract (Santolina chamaecyparissus L., Asteraceae)

Horticulturae
Cotton lavender (Santolina chamaecyparissus L., Asteraceae) is a widespread medicinal and ornamental plant. This study aimed to evaluate the preliminary and detailed chemical composition as well as the biological activity of ethanolic extract. As part of
Katarina Radovanović, Dajana Vukić, Nebojša Kladar, Maja Hitl, Neda Gavarić, Milica Aćimović   +5 more
doaj   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

In silico modelling of tumour-induced angiogenesis

, 2014
Angiogenesis, the process by which new vessels form from existing ones, is a key event in the development of a large and malignant vascularised tumour. A rapid expansion in in vivo and in vitro angiogenesis research in recent years has led to increased knowledge about the processes underlying angiogenesis and to promising steps forward in the ...
openaire   +2 more sources

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Consensus approach for modeling HTS assays using in silico descriptors

, 2016
The need for filling information gaps while reducing toxicity testing in animals is becoming more predominant in risk assessment. Recent legislations are accepting in silico approaches for predicting toxicological outcomes.
Hilde eSpahn-Langguth, Karl eWerner-Schramm, Ahmed eAbdelaziz Sayed, Igor V. Tetko   +3 more
core   +1 more source

FARFOOD: a database of potential interactions between food compounds and drugs

BioData Mining
Nutrition is a fundamental aspect in human life development, both from a socio-economic and medical perspective. In recent years, new personalized approaches have been added to the biochemical study of nutrients. These approaches consider both the effect
Ana María Nevado-Bulnes, Dixan Agustin Benitez, Guadalupe Cumplido-Laso, Jose María Carvajal-González, Sonia Mulero-Navarro, Angel-Carlos Román   +5 more
doaj   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

In silico human cardiomyocyte action potential modeling : exploring ion channel input combinations

In silico modeling offers an opportunity to supplement and accelerate cardiac safety testing. With in silico modeling, computational simulation methods are used to predict electrophysiological interactions and pharmacological effects of novel drugs on ...
Boulay, Emmanuel, Jacquemet, Vincent, Huang, Hai, Pugsley, Michael, Troncy, Éric, Venegas Baca, Rafael, Downey, Anne-Marie, Authier, Simon   +7 more
core   +1 more source

In silico modeling and in vivo efficacy of cancer preventive vaccinations

, 2010
Cancer vaccine feasibility would benefit from reducing the number and duration of vaccinations without diminishing efficacy. However, the duration of in vivo studies and the huge number of possible variations in vaccination protocols have discouraged ...
NICOLETTI, GIORDANO, Marianna L. Ianzano, Valentina Grosso, PALLADINI, ARIANNA, NANNI, PATRIZIA, V. Grosso, Agnese Antognoli, ANTOGNOLI, AGNESE, LOLLINI, PIER LUIGI, LANDUZZI, LORENA, Arianna Palladini, S. Motta, Francesco Pappalardo, IANZANO, MARIANNA LUCIA, Patrizia Nanni, Carla De Giovanni, Annalisa Murgo, STIVANI, VALERIA, Valeria Stivani, F. Pappalardo, CROCI, STEFANIA, Pier-Luigi Lollini, Lorena Landuzzi, DE GIOVANNI, CARLA, Santo Motta, MURGO, ANNALISA, Giordano Nicoletti, Stefania Croci   +27 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source