Results 171 to 180 of about 165,849 (202)

IN SILICO MODELS OF ACUTE INFLAMMATION IN ANIMALS

Shock, 2006
Trauma and hemorrhagic shock elicit an acute inflammatory response, predisposing patients to sepsis, organ dysfunction, and death. Few approved therapies exist for these acute inflammatory states, mainly due to the complex interplay of interacting inflammatory and physiological elements working at multiple levels.
Yoram, Vodovotz, Carson C, Chow, John, Bartels, Claudio, Lagoa, Jose M, Prince, Ryan M, Levy, Rukmini, Kumar, Judy, Day, Jonathan, Rubin, Greg, Constantine, Timothy R, Billiar, Mitchell P, Fink, Gilles, Clermont   +12 more
openaire   +2 more sources

In silico modelling--pharmacophores and hERG channel models.

Novartis Foundation symposium, 2005
In computational drug design, modelling studies are undertaken following two main strategies that depend on which information is available. If experimental data exist only for the molecules displaying the biological property of interest, a so-called ligand-based approach is taken; if information is available on the macromolecular target(s) of the ...
RECANATINI, MAURIZIO, CAVALLI, ANDREA, MASETTI, MATTEO   +2 more
openaire   +2 more sources

In Silico Models for Acute Systemic Toxicity

2016
In this chapter, we give an overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review the availability of structure-based computational models that are available and potentially useful in the assessment of acute systemic toxicity. The most recently published literature models for acute systemic
Julien, Burton, Andrew P, Worth, Ivanka, Tsakovska, Antonia, Diukendjieva   +3 more
openaire   +2 more sources

In Silico Models

2022
Daniel J. Pope, Robert Fryer, Spyros D. Masouros   +2 more
openaire   +1 more source

Modeling condensate formation in silico

Nature Methods, 2022
openaire   +2 more sources

Integrative biological modelling in silico.

Novartis Foundation symposium, 2003
In silico models of biological systems provide a powerful tool for integrative analysis of physiological function. Using the computational models of the heart as examples, we discuss three types of integration: structural integration implies integration across physical scales of biological organization from protein molecule to whole organ; functional ...
Andrew D, McCulloch, Gary, Huber
openaire   +1 more source

In Silico ADME Modeling

2021
Ioana Oprisiu, Susanne Winiwarter
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

In-Silico ADME Modeling

2006
Hans Matter, Wolfgang Schmider
openaire   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly