Results 181 to 190 of about 93,106 (305)

Identification of Potent HDAC6 Inhibitors for Breast Cancer Through Multi-Stage In Silico Modeling. [PDF]

Bioinform Biol Insights
Pankaj V, Bhogal I, Roy S.
europepmc   +1 more source

A Comparative Evaluation of Desoximetasone Cream and Ointment Formulations Using Experiments and In Silico Modeling. [PDF]

Int J Mol Sci, 2023
Matharoo NS, Garimella HT, German C, Przekwas AJ, Michniak-Kohn B.   +4 more
europepmc   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

In silico modeling of a clinical photon-counting CT system: Verification and validation. [PDF]

Med Phys
McCabe C, Harrawood B, Samei E, Abadi E.
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Multiscale Modeling Is Required for the Patent Ductus Arteriosus in Preterm Infants

Frontiers in Pediatrics, 2022
Harvey Ho, Xiaojuan Ji
doaj   +1 more source

In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm. [PDF]

PLoS Comput Biol
Mostofinejad A, Romero DA, Brinson D, Waddell TK, Karoubi G, Amon CH.   +5 more
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Personalized mapping of inhibitory spinal cord circuits in humans via noninvasive neural decoding and in silico modeling. [PDF]

Sci Adv
Pascual-Valdunciel A, Cónsul NT, Brownstone RM, Beato M, Farina D, Nascimento F, Özyurt MG.   +6 more
europepmc   +1 more source

In Silico Modeling: the Human Factor

Humana.Mente: Journal of Philosophical Studies, 2016
Bertolaso, Marta, MacLeod, Miles Alexander James   +1 more
openaire   +2 more sources