Results 171 to 180 of about 167,809 (296)

Identification of Potent HDAC6 Inhibitors for Breast Cancer Through Multi-Stage In Silico Modeling. [PDF]

Bioinform Biol Insights
Pankaj V, Bhogal I, Roy S.
europepmc   +1 more source

In Silico Modeling and Structural Analysis of Soluble Epoxide Hydrolase Inhibitors for Enhanced Therapeutic Design. [PDF]

Molecules, 2023
Sar S, Mitra S, Panda P, Mandal SC, Ghosh N, Halder AK, Cordeiro MNDS.   +6 more
europepmc   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm. [PDF]

PLoS Comput Biol
Mostofinejad A, Romero DA, Brinson D, Waddell TK, Karoubi G, Amon CH.   +5 more
europepmc   +1 more source

LEUKOCYTE PHENOTYPING IN SEPSIS USING OMICS, FUNCTIONAL ANALYSIS, AND IN SILICO MODELING. [PDF]

Shock, 2023
Langston JC, Yang Q, Kiani MF, Kilpatrick LE.   +3 more
europepmc   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

In Silico Modeling Validation and Contact Pressure Distribution Comparison Analysis of Conventional and Robotic-Assisted Unicompartmental Knee Arthroplasty. [PDF]

JB JS Open Access
Park Y, Elbert K, Koh J, Amirouche F.
europepmc   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Multiscale Modeling Is Required for the Patent Ductus Arteriosus in Preterm Infants

Frontiers in Pediatrics, 2022
Harvey Ho, Xiaojuan Ji
doaj   +1 more source

Comparing Mediterranean, Dietary Phytochemical Index, and Healthy Eating Indices with a Theoretical Model of a Dental Diet Risk Score: An In-Silico Modeling Study. [PDF]

Cureus
Cagiran Gorgin N, Cagiran Yilmaz F.
europepmc   +1 more source