Results 261 to 270 of about 167,809 (296)

In Silico Models for Hepatotoxicity

2016
In this chapter we review the challenges of predicting human hepatotoxicity. Principally, this is our partial understanding of a very complex biochemical system and our ability to emulate that in a predictive capacity. We give an overview of the published modeling approaches in this area to date and discuss their design, strengths, and weaknesses.
Mark, Hewitt, Katarzyna, Przybylak
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In silico modelling of physiologic systems

Best Practice & Research Clinical Anaesthesiology, 2011
In silico modelling, in which computer models are developed to model a pharmacologic or physiologic process, is a logical extension of controlled in vitro experimentation. It is the natural result of the explosive increase in computing power available to the research scientist at continually decreasing cost.
Richard B, Colquitt, Douglas A, Colquhoun, Robert H, Thiele   +2 more
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In Silico Modeling of Crabtree Effect

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2017
Glycolytic activity during Crabtree effect is similar to that in tumor cells. Research regarding Crabtree effect is very much crucial.The mechanism of metabolic activities in glycolysis pathway and oxidative phosphorylation pathway in regards to Crabtree effect in Saccharomyces cerevisiae was studied in this paper.
Debraj, Ghosh, Rajat K, De
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A Hyperneuron Model Towards in Silico Implementation

International Journal of Bifurcation and Chaos, 2022
In this paper, the concept of hyperneuron is introduced. The main properties and dynamical characteristics of this class of hypersystems will be studied by numerical analysis. The intrinsic robustness of the proposed model is further investigated by proposing a silicon implementation of the hyperneuron, reporting the corresponding experimental results.
Branciforte M., Buscarino A., Fortuna L.
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In Silico Blood Pressure Models Comparison

IEEE Sensors Journal, 2022
As cardiovascular diseases (CVDs) are one of the most prominent illnesses, continuous, noninvasive, and comfortable monitoring of blood pressure (BP) is indispensable. This article investigates the best method for obtaining highly accurate BP values in noninvasive measurements through the extraction of hemodynamic variables from the arteries of young ...
Ana Carolina Goncalves Seabra, Alexandre Ferreira da Silva, Thomas Stieglitz, Ana Belen Amado-Rey   +3 more
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In Silico Models for Nanomedicine: Recent Developments

Current Medicinal Chemistry, 2018
Nanomedicine is a recent promising setting for the advancement of current medical therapies, in particular for cancer. Nanoparticle-mediated therapies are aimed to tackle extremely complex phenomena, involving different biochemical, mechanical and biophysical factors.
Pietro, Mascheroni, Bernhard Aribo, Schrefler   +1 more
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In Silico Models for Skin Sensitization and Irritation

2022
The assessment of skin irritation, and in particular of skin sensitization, has undergone an evolution process over the last years, pushing forward to new heights of quality and innovation. Public and commercial in silico tools have been developed for skin sensitization and irritation, introducing the possibility to simplify the evaluation process and ...
Gianluca, Selvestrel, Federica, Robino, Matteo Zanotti, Russo   +2 more
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Evolution in Silico and in Vitro: The RNA Model

Biological Chemistry, 2001
Theoretical concepts and experiments dealing with the evolution of molecules in vitro reached a state that allows for direct applications to the design of biomolecules with predefined properties. RNA evolution in vitro represents a basis for the development of a new and comprehensive model of evolution, focusing on the phenotype and its fitness ...
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Metabolic modeling of microbial strains in silico

Trends in Biochemical Sciences, 2001
The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of ...
M W, Covert, C H, Schilling, I, Famili, J S, Edwards, I I, Goryanin, E, Selkov, B O, Palsson   +6 more
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IN SILICO MODELS OF ACUTE INFLAMMATION IN ANIMALS

Shock, 2006
Trauma and hemorrhagic shock elicit an acute inflammatory response, predisposing patients to sepsis, organ dysfunction, and death. Few approved therapies exist for these acute inflammatory states, mainly due to the complex interplay of interacting inflammatory and physiological elements working at multiple levels.
Yoram, Vodovotz, Carson C, Chow, John, Bartels, Claudio, Lagoa, Jose M, Prince, Ryan M, Levy, Rukmini, Kumar, Judy, Day, Jonathan, Rubin, Greg, Constantine, Timothy R, Billiar, Mitchell P, Fink, Gilles, Clermont   +12 more
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