Results 111 to 120 of about 169,778 (256)

Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models. [PDF]

Arch Toxicol, 2023
Kopańska K, Rodríguez-Belenguer P, Llopis-Lorente J, Trenor B, Saiz J, Pastor M.   +5 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Editorial: Biotribology and Biotribocorrosion Properties of Implantable Biomaterials

Frontiers in Mechanical Engineering, 2020
Alessandro Ruggiero, Hongyu Zhang
doaj   +1 more source

Mechanistic modelling of allergen-induced airways disease in early life

Scientific Reports
Asthma affects approximately 300 million individuals worldwide and the onset predominantly arises in childhood. Children are exposed to multiple environmental irritants, such as viruses and allergens, that are common triggers for asthma onset, whilst ...
Hannah J. Pybus, Prakrati Dangarh, Man Yin Melanie Ng, Clare M. Lloyd, Sejal Saglani, Reiko J. Tanaka   +5 more
doaj   +1 more source

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

Evolvoid: a genetic algorithm for shaping optimal cellular constructs

Journal of Biological Engineering
Background Accurate cellular models are critical for understanding tissue function and accelerating drug discovery. While in vitro systems like spheroids and organoids are widely used, they are costly, low-throughput, and often lack reproducibility. Here,
Piera Mancini, Flavio Fontana, Ermes Botte, Chiara Magliaro, Francesco Pampaloni, Arti Ahluwalia   +5 more
doaj   +1 more source

Metabolic Models, in Silico Trials, and Algorithms

Diabetes Technology & Therapeutics
Artificial pancreas (AP) systems, also called automated insulin delivery systems, have improved the time in range of glucose levels, reduced the daily burden of the user for glucose regulation, and improved their quality of life. Several commercially available AP systems operate in hybrid closed-loop mode that requires manual information from the user ...
Ali Cinar, Ananda Basu, B. Wayne Bequette, Marc D. Breton, Bruce Buckingham, Eda Cengiz, Claudio Cobelli, Eyal Dassau, Francis J. Doyle, Chiara Fabris, Andrea Facchinetti, Irl Hirsch, Roman Hovorka, Peter G. Jacobs, Boris P. Kovatchev, Chiara Dalla Man, Laurie Quinn, Jay Skyler   +17 more
openaire   +3 more sources

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Editorial: Systems biology, women in science 2021/22: translational systems biology and in silico trials

Frontiers in Systems Biology, 2023
Jane A. Leopold, Madhavi K. Ganapathiraju, Naveena Yanamala   +2 more
doaj   +1 more source