Results 101 to 110 of about 170,795 (287)
Humana.Mente: Journal of Philosophical Studies, 2016 In this article, which is assembled from interviews, the main issues of in silico medicine, present and future, are discussed by three scientists who are directly involved in the implementation and development of in silico techniques.
Matteo Cerri +2 more
doaj
BMC Bioinformatics, 2017 Background We present a software workflow capable of building large scale, highly detailed and realistic volumetric models of neocortical circuits from the morphological skeletons of their digitally reconstructed neurons.
Marwan Abdellah +5 more
doaj +1 more source
Methods for the Development of In Silico GPCR Models [PDF]
, 2017 The Reggio group has constructed computer models of the inactive and G-protein-activated states of the cannabinoid CB1 and CB2 receptors, as well as, several orphan receptors that recognize a subset of cannabinoid compounds, including GPR55 and GPR18. These models have been used to design ligands, mutations, and covalent labeling studies. The resultant
Paula, Morales +2 more
openaire +2 more sources
, 2019 Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783) +6 more
core +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
, 2019 Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
David Pamies (1750783) +6 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Development of an in silico hybrid model for scoliosis correction using Ansys Motion
Computer Assisted SurgerySurgical techniques for correcting scoliotic deformities are continuously evolving, and computer modeling has become a valuable tool to support surgeons in testing and optimizing spinal instrumentation and corrective strategies.
Damiano Simeoni +4 more
doaj +1 more source
In Silico Models to Validate Novel Blood-Based Biomarkers.
Biological validation of preliminary findings is a key prerequisite in biomarker discovery. In recent years, the development of advanced large-scale sequencing technologies combined with high-throughput computational analysis methods led to the ...
Sadlon, Angélique
core +1 more source
Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes [PDF]
, 2009 BackgroundA growing number of realistic in silico models of metabolic functions are being formulated and can serve as 'dry lab' platforms to prototype and simulate experiments before they are performed.
Bernhard O Palsson +3 more
core +1 more source