Results 81 to 90 of about 170,795 (287)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Foods represent complex mixtures of constituents and contaminants, some of which may pose risks to health through genotoxic effects. We investigated the current capabilities and limitations of a data-driven approach for the systematic identification of ...
Menz, Jakob, Schäfer, Bernd
core +1 more source
Applicability domain for in silico models to achieve accuracy of experimental measurements.
, 2010 The accuracy of in silico models can be inhomogeneous: models can show excellent performance on some chemical subspaces but have low accuracy on others.
Anil Kumar Pandey +13 more
core +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Food Science and Human Wellness, 2016 The interest in food toxicology is evident by the dependency of humankind on nutrition by virtue of their heterotrophic metabolism. By means of modern biochemistry, molecular and cell biology, computer science, bioinformatics as well as high-throughput ...
Alexander Gosslau
doaj +1 more source
In silico modelling of hormone response elements [PDF]
BMC Bioinformatics, 2006 Abstract Background An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is a challenging problem to establish an accurate model for ...
Maria Stepanova +2 more
openaire +2 more sources
Dataset - In Silico Models of the Macromolecular NaV1.5-KIR2.1 Complex
<p>Supplemental material to the study "In Silico Models of the Macromolecular NaV1.5-KIR2.1 Complex", published in Front. Physiol.</p> <p> </p> <p>The models uploaded correspond to the coordinates shown in Figure ...
Stary-Weinzinger, Anna
core +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
In Silico 3D Modeling of Binding Activities
, 2016 In silico three-dimensional (3D) molecular modeling tools based upon the receptor/enzyme-ligand docking simulation in protein crystal structures and/or homology modeling of receptors have been reliably used in pharmacological research and development for decades.
MORO, STEFANO +3 more
openaire +4 more sources