Results 61 to 70 of about 170,795 (287)

Computational Approaches in Theranostics: Mining and Predicting Cancer Data

Pharmaceutics, 2019
The ability to understand the complexity of cancer-related data has been prompted by the applications of (1) computer and data sciences, including data mining, predictive analytics, machine learning, and artificial intelligence, and (2) advances in ...
Tânia F. G. G. Cova, Daniel J. Bento, Sandra C. C. Nunes   +2 more
doaj   +1 more source

Workflow of in silico models to evaluete the toxicity of pesticide residues, drugs and metabolites in natural waters

, 2023
Constantly we have to deal with an exponential increase in the amount of different chemical compounds that industries synthesize and manufacture, such as drugs, pesticides, persistent organic pollutants, preservatives, and personal hygiene products. Many
Alves, Marcelo Siqueira, Streit, Lívia, Pizzolato, Tania Mara   +2 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Computational Methods as Part of Scientific Research in Cosmetic Sciences—Are We Using the Opportunity?

Cosmetics
In the field of the cosmetic industry, significant efforts are made to develop methods that are not only cost effective and time effective but are also environmentally friendly and cruelty free.
Laura Krumpholz, Sebastian Polak, Barbara Wiśniowska   +2 more
doaj   +1 more source

Development of In Vitro Corneal Models: Opportunity for Pharmacological Testing

Methods and Protocols, 2020
The human eye is a specialized organ with a complex anatomy and physiology, because it is characterized by different cell types with specific physiological functions.
Valentina Citi, Eugenia Piragine, Simone Brogi, Sara Ottino, Vincenzo Calderone   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Building Australia’s non-animal technologies ecosystem: a national cross-sector mapping and strategic insights from the non-animal technologies network (NAT-Net)

Frontiers in Toxicology
BackgroundNon-animal technologies (NATs; also termed new approach methodologies, NAMs) are rapidly reshaping biomedical research, safety testing and drug development by improving human relevance and reducing reliance on animal models.
Shafagh A. Waters, Shafagh A. Waters, Shafagh A. Waters, Adam P. Hill, Adam P. Hill, Adam P. Hill, Esther S. Pronker, Gerard E. Kaiko, Gerard E. Kaiko, Gungun Lin, Gungun Lin, Simon Keely, Simon Keely, Simon Keely, Laura Collie, Laura Collie, Laura Collie, Wojciech Chrzanowski, Wojciech Chrzanowski, Wojciech Chrzanowski, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero   +22 more
doaj   +1 more source

Prediction of Aerosol Deposition in the Human Respiratory Tract via Computational Models: A Review with Recent Updates

Atmosphere, 2020
The measurement of deposited aerosol particles in the respiratory tract via in vivo and in vitro approaches is difficult due to those approaches’ many limitations.
Vu Khac Hoang Bui, Ju-Young Moon, Minhe Chae, Duckshin Park, Young-Chul Lee   +4 more
doaj   +1 more source

In Silico Modelling of the Human Intestinal Microflora [PDF]

, 2002
The ecology of the human intestinal microflora and its interaction with the host are poorly understood. Though more and more data are being acquired, in part using modern molecular methods, development of a quantitative theory has not kept pace with this development.
Derk Jan Kamerman, Michael H. F. Wilkinson   +1 more
openaire   +2 more sources

Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax [PDF]

, 2021
The pig has been increasingly used as a reliable preclinical model for assessing and predicting the in vivo bioavailability of different formulation strategies. Nevertheless, differences in the composition between porcine and human intestinal fluids, may
Koehl, Niklas J., Holm, René, Griffin, Brendan T., Henze, Laura J., O'Shea, Joseph P., O\u27Shea, Joseph P., Vertzoni, Maria   +6 more
core   +1 more source