Results 51 to 60 of about 170,795 (287)
Cell-Based Computational Models of Organoids: A Systematic Review
CellsOrganoids are self-organizing multicellular structures generated in vitro that recapitulate the micro-architecture and function of an organ. They are commonly derived from stem cells but can also emerge from pieces of proliferative tissues.
Monica Neagu +3 more
doaj +1 more source
Environment International, 2021 Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific ...
J.L.C.M. Dorne +25 more
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Modeling ChIP Sequencing In Silico with Applications
PLoS Computational Biology, 2008 ChIP sequencing (ChIP-seq) is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the binding sites must be properly modeled.
Zhengdong D. Zhang +4 more
openaire +3 more sources
Ontogenetic and in silico models of spatial‐packing in the hypermuscular mouse skull [PDF]
, 2021 Networks linking single genes to multiple phenotypic outcomes can be founded on local anatomical interactions as well as on systemic factors like biochemical products.
Mendias, Christopher +8 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Integrating In-Silico Models with In-Vitro Data to Generate Novel Insights into Biological Systems [PDF]
, 2019 Models and computational predictions are useful in identifying certain key parameters that play a central role in defining the overall behavior of the system, and thus lead to new and more informative experiments.
Conway, Darren
core +2 more sources
, 2019 This article dwells on the nature of “inverted bonds”, which make reference to the σ interaction between two s-p hybrids by their smaller lobes, and their presence in [1.1.1]propellane 1.
Patrick, Chaquin +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Molecular BiosciencesIntroductionAdvances in molecular targeting of ion channels may open up new avenues for therapeutic approaches in cancer based on the cells’ bioelectric properties.
Sonja Langthaler +13 more
doaj +1 more source