Results 41 to 50 of about 169,778 (256)

Computational Methods as Part of Scientific Research in Cosmetic Sciences—Are We Using the Opportunity?

Cosmetics
In the field of the cosmetic industry, significant efforts are made to develop methods that are not only cost effective and time effective but are also environmentally friendly and cruelty free.
Laura Krumpholz, Sebastian Polak, Barbara Wiśniowska   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Building Australia’s non-animal technologies ecosystem: a national cross-sector mapping and strategic insights from the non-animal technologies network (NAT-Net)

Frontiers in Toxicology
BackgroundNon-animal technologies (NATs; also termed new approach methodologies, NAMs) are rapidly reshaping biomedical research, safety testing and drug development by improving human relevance and reducing reliance on animal models.
Shafagh A. Waters, Shafagh A. Waters, Shafagh A. Waters, Adam P. Hill, Adam P. Hill, Adam P. Hill, Esther S. Pronker, Gerard E. Kaiko, Gerard E. Kaiko, Gungun Lin, Gungun Lin, Simon Keely, Simon Keely, Simon Keely, Laura Collie, Laura Collie, Laura Collie, Wojciech Chrzanowski, Wojciech Chrzanowski, Wojciech Chrzanowski, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero   +22 more
doaj   +1 more source

Computational Approaches in Theranostics: Mining and Predicting Cancer Data

Pharmaceutics, 2019
The ability to understand the complexity of cancer-related data has been prompted by the applications of (1) computer and data sciences, including data mining, predictive analytics, machine learning, and artificial intelligence, and (2) advances in ...
Tânia F. G. G. Cova, Daniel J. Bento, Sandra C. C. Nunes   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The bioelectric mechanisms of local calcium dynamics in cancer cell proliferation: an extension of the A549 in silico cell model

Frontiers in Molecular Biosciences
IntroductionAdvances in molecular targeting of ion channels may open up new avenues for therapeutic approaches in cancer based on the cells’ bioelectric properties.
Sonja Langthaler, Christian Zumpf, Theresa Rienmüller, Niroj Shrestha, Niroj Shrestha, Julia Fuchs, Julia Fuchs, Rui Zhou, Brigitte Pelzmann, Klaus Zorn-Pauly, Eleonore Fröhlich, Seth H. Weinberg, Seth H. Weinberg, Christian Baumgartner   +13 more
doaj   +1 more source

Development of In Vitro Corneal Models: Opportunity for Pharmacological Testing

Methods and Protocols, 2020
The human eye is a specialized organ with a complex anatomy and physiology, because it is characterized by different cell types with specific physiological functions.
Valentina Citi, Eugenia Piragine, Simone Brogi, Sara Ottino, Vincenzo Calderone   +4 more
doaj   +1 more source

In Silico Modelling of the Human Intestinal Microflora [PDF]

, 2002
The ecology of the human intestinal microflora and its interaction with the host are poorly understood. Though more and more data are being acquired, in part using modern molecular methods, development of a quantitative theory has not kept pace with this development.
Derk Jan Kamerman, Michael H. F. Wilkinson   +1 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source