Results 41 to 50 of about 170,795 (287)

In-silico modeling of granulomatous diseases [PDF]

Current Opinion in Pulmonary Medicine, 2016
The pathogenesis of genetically complex granulomatous diseases, such as sarcoidosis and latent tuberculosis, remains largely unknown. With the recent advent of more powerful research tools, such as genome-wide expression platforms, comes the challenge of making sense of the enormous data sets so generated. This manuscript will provide demonstrations of
openaire   +2 more sources

Environmental Hazard Screening of Heterocyclic Polyaromatic Hydrocarbons: Physicochemical Data and In Silico Models

, 2022
Heterocyclic polyaromatic hydrocarbons (heterocyclic PAHs) are frequently found in the environment yet, compared to homocyclic PAHs, little attention has been paid to their environmental behavior and a comprehensive hazard assessment has not been ...
Stefan Stolte (1976089), Stephan Beil (14289871), Marta Markiewicz (1941007), Göksu Çelik (14289868)   +3 more
core   +2 more sources

Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration

JOR Spine, 2023
Background A significant hurdle for potential cell‐based therapies is the subsequent survival and regenerative capacity of implanted cells. While many exciting developments have demonstrated promise preclinically, cell‐based therapies for intervertebral ...
Emily E. McDonnell, Niamh Wilson, Marcos N. Barcellona, Tara Ní Néill, Jessica Bagnall, Pieter A. J. Brama, Gráinne M. Cunniffe, Stacey L. Darwish, Joseph S. Butler, Conor T. Buckley   +9 more
doaj   +1 more source

Ecotoxicological Evaluation of Bisphenol A and Alternatives: A Comprehensive In Silico Modelling Approach

Journal of Xenobiotics, 2023
Bisphenol A (BPA), a compound widely used in industrial applications, has raised concerns due to its environmental impact. As a key component in the manufacture of polycarbonate plastics and epoxy resins used in many consumer products, concerns about ...
Liadys Mora Lagares, Marjan Vračko
doaj   +1 more source

Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials

Nanomaterials, 2022
The increasing growth in the development of various novel nanomaterials and their biomedical applications has drawn increasing attention to their biological safety and potential health impact.
Alexey A. Tsukanov, Boris Turk, Olga Vasiljeva, Sergey G. Psakhie   +3 more
doaj   +1 more source

Role of the osteocyte in bone metastasis – The importance of networking

Journal of Bone Oncology
Metastatic bone disease is a complex condition resulting from the migration and colonization of cancer cells from their primary site to the bone microenvironment, where they typically develop a metastatic niche.
Stefaan W. Verbruggen
doaj   +1 more source

Analytical and computational studies predict negligible risk of cell death from eddy generation off flat surfaces in cell culture flow systems

Frontiers in Bioengineering and Biotechnology
Cell-based therapies represent the current frontier of biomedical innovations, with the technologies required underpinning treatments as broad as CAR-T cell therapies, stem cell treatments, genetic therapies and mRNA manufacture.
Elliot J. Morley, Claire L. Brockett, Claire L. Brockett, Stefaan W. Verbruggen, Stefaan W. Verbruggen, Stefaan W. Verbruggen, Stefaan W. Verbruggen   +6 more
doaj   +1 more source

IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS. [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Because the oral route of drug delivery is incomparable, screening of intestinal permeability and absorption of drug candidates is a critical stage before clinical trials for time and cost reasons.
Ahmed Elgendy, Adeboye Adejare, Saleh Abd El-Rasoul, Abdullah Asiri   +3 more
doaj   +1 more source

Review of in silico models of cerebral blood flow in health and pathology

, 2023
In this review, we provide a summary of the state-of-the-art in the in silico modelling of cerebral blood flow and its application in in silico clinical trials.
Payne, Stephen John, Stephen Payne, el-Bouri, Wahbi K., El-Bouri, Wahbi, Józsa, Tamás István, Wahbi K El-Bouri, Tamás István Józsa, Payne, Stephen J., Józsa, Tamás I., Payne, Stephen   +9 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source