Results 31 to 40 of about 170,795 (287)
Enabling rational gut microbiome manipulations by understanding gut ecology through experimentally-evidenced in silico models. [PDF]
Gut Microbes, 2021 The gut microbiome has emerged as a contributing factor in non-communicable disease, rendering it a target of health-promoting interventions. Yet current understanding of the host-microbiome dynamic is insufficient to predict the variation in ...
Molina Ortiz JP +5 more
europepmc +3 more sources
Relationship Between Adverse Outcome Pathways and Chemistry-Based in Silico Models to Predict Toxicity [PDF]
, 2017 The current landscape of Adverse Outcome Pathways (AOPs) provides a means of organising information relating to the adverse effects elicited following exposure to chemicals.
Richarz, A +3 more
core +2 more sources
In Silico Models for Ecotoxicity of Pharmaceuticals [PDF]
, 2016 Pharmaceuticals and their active metabolites are one of the significantly emerging environmental toxicants. The major routes of entry of pharmaceuticals into the environment are industries, hospitals, or direct disposal of unwanted or expired drugs made by the patient.
Roy, Kunal, Kar, Supratik
openaire +2 more sources
Structural Equation Modeling of In silico Perturbations [PDF]
Frontiers in Genetics, 2021 Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in humans.
Jianying Li +12 more
openaire +5 more sources
Basic & Clinical Cancer Research, 2019 Hyperthermia is a novel method for cancer therapy. To have the best control when heating tissues in hyperthermia, the use of magnetic nanoparticles is suggested.
Zahra Zahedi-Tabar +3 more
doaj +1 more source
In silico modeling in infectious disease
Drug Discovery Today: Disease Models, 2007 Infectious disease has witnessed the emergence of mathematical modeling a tool of synthesizing data of growing complexity now available to clinicians and basic scientists alike. The purpose of this review is to introduce mathematical tools commonly used to model infectious disease.
Daun, Silvia, Clermont, Gilles
openaire +2 more sources
In silico Prediction of Skin Sensitization: Quo vadis?
Frontiers in Pharmacology, 2021 Skin direct contact with chemical or physical substances is predisposed to allergic contact dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the contacted skin area.
Giang Huong Ta +2 more
doaj +1 more source
In silico modelling of DNA nanostructures
Computational and Structural Biotechnology Journal, 2020 The rise of material science and nanotechnology created a demand for a next generation of materials and procedures that can transcend the shaping of simple geometrical nano-objects. As a legacy of the technological progress made in the Human Genome Project, DNA was identified as a possible candidate.
Kekic, Tadija, Barisic, Ivan
openaire +3 more sources
In silico Models of Alcohol Dependence and Treatment [PDF]
Frontiers in Psychiatry, 2012 In this paper we view alcohol dependence and the response to treatment as a recurrent bio-behavioral process developing in time and propose formal models of this process combining behavior and biology in silico. The behavioral components of alcohol dependence and treatment are formally described by a stochastic process of human behavior, which serves ...
Kovatchev, Boris +2 more
openaire +3 more sources
, 2022 Subcutaneous injection is a commonly used route of drug administration for both small molecules and biologics. To facilitate the development of new subcutaneously administered drugs, methods for prediction of drug absorption from the injection site are ...
Sjögren, Erik, +3 more
core +1 more source