Results 11 to 20 of about 169,778 (256)
In Silico Hemostasis Modeling and Prediction [PDF]
Hämostaseologie, 2020 AbstractComputational physiology, i.e., reproduction of physiological (and, by extension, pathophysiological) processes in silico, could be considered one of the major goals in computational biology. One might use computers to simulate molecular interactions, enzyme kinetics, gene expression, or whole networks of biochemical reactions, but it is (patho)
Dmitry Y, Nechipurenko +3 more
openaire +2 more sources
Assessment of Vehicle Volatility and Deposition Layer Thickness in Skin Penetration Models
Pharmaceutics, 2021 Systemic disposition of dermally applied chemicals is often formulation-dependent. Rapid evaporation of the vehicle can result in crystallization of active compounds, limiting their degree of skin penetration.
Abdullah Hamadeh +2 more
doaj +1 more source
Frontiers in Oncology, 2021 In silico models of biomolecular regulation in cancer, annotated with patient-specific gene expression data, can aid in the development of novel personalized cancer therapeutic strategies.
Mahnoor Naseer Gondal +11 more
doaj +1 more source
Modeling Neurodegeneration in silico With Deep Learning [PDF]
Frontiers in Neuroinformatics, 2021 Deep neural networks, inspired by information processing in the brain, can achieve human-like performance for various tasks. However, research efforts to use these networks as models of the brain have primarily focused on modeling healthy brain function so far.
Anup Tuladhar +13 more
openaire +3 more sources
The Scope and Limitations of In Vivo and In Silico Models of Cardiac Amyloidosis
Engineering Proceedings, 2023 Amyloidosis is a systemic disease, leading to the disfunction of many organs. There are several clinical and morphological forms of amyloidosis based on the organ-specific nature of amyloid fibril deposition, which is found in the heart, brain, kidneys ...
Svetlana Morozkina +2 more
doaj +1 more source
Critical Care Medicine, 2013 To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.PubMed search and review of relevant medical literature.Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole ...
Yoram, Vodovotz, Timothy R, Billiar
openaire +2 more sources
Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk
Cell Reports Medicine, 2020 Summary: There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of
Mark R. Davies +11 more
doaj +1 more source
In silico models of cancer [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractCancer is a complex disease that involves multiple types of biological interactions across diverse physical, temporal, and biological scales. This complexity presents substantial challenges for the characterization of cancer biology, and motivates the study of cancer in the context of molecular, cellular, and physiological systems ...
Lucas B, Edelman +2 more
openaire +2 more sources
Experimental Models as Refined Translational Tools for Breast Cancer Research
Scientia Pharmaceutica, 2020 Breast cancer is one of the most common cancers worldwide, which makes it a very impactful malignancy in the society. Breast cancers can be classified through different systems based on the main tumor features and gene, protein, and cell receptors ...
Eduardo Costa +5 more
doaj +1 more source
In Silico Models for Drug Resistance [PDF]
, 2013 Resistance to drugs that treat infectious disease is a major problem worldwide. The rapid emergence of drug resistance is not well understood. We present two in silico models for the discovery of drug resistance mechanisms and for combating the evolution of resistance, respectively.
Fatumo, S. +2 more
openaire +3 more sources