Applications of In Silico Models to Predict Drug-Induced Liver Injury [PDF]
Toxics, 2022 Drug-induced liver injury (DILI) is a major cause of the withdrawal of pre-marketed drugs, typically attributed to oxidative stress, mitochondrial damage, disrupted bile acid homeostasis, and innate immune-related inflammation.
Jiaying Lin +7 more
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Semantically Linking In Silico Cancer Models [PDF]
Cancer Informatics, 2014 Multiscale models are commonplace in cancer modeling, where individual models acting on different biological scales are combined within a single, cohesive modeling framework. However, model composition gives rise to challenges in understanding interfaces
David Johnson +6 more
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MicroorganismsInvestigating the complex interactions between microbiota and immunity is crucial for a fruitful understanding progress of human health and disease. This review assesses animal models, next-generation in vitro models, and in silico approaches that are ...
Sara Bertorello +4 more
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Alternative in vitro and in silico models to reduce animal use: a crucial technological advance in dermatological sciences [PDF]
Expert Reviews in Molecular MedicineIntroduction Alternative models are tools to replace and reduce the number of animals used in biomedical sciences, for either research or tests of industrial products. Several new alternative models have been developed in the most diverse fields.
Carla Zanatelli +3 more
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Platform design of hybrid microphysiological system integrating in vitro and in silico models for reproducing insulin-regulated glucose metabolism [PDF]
Scientific ReportsThis study presents a hybrid platform for microphysiological systems (MPS) that combines in vitro organ-on-a-chip (OoC) technology and an in silico model. In this platform, in silico models act as virtual organs that interact with real OoCs, enabling the
Satoshi Konishi +4 more
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Molecules, 2019 Phenols are the most abundant naturally accessible antioxidants present in a human normal diet. Since numerous beneficial applications of phenols as preventive agents in various diseases were revealed, the evaluation of phenols bioavailability is of high
Katja Venko, Marjana Novič
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The VEGA Tool to Check the Applicability Domain Gives Greater Confidence in the Prediction of In Silico Models. [PDF]
Int J Mol Sci, 2023 Danieli A +9 more
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In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies. [PDF]
Cancers (Basel), 2022 Bekisz S +4 more
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In Silico Modeling: the Human Factor
Humana.Mente: Journal of Philosophical Studies, 2016 Marta Bertolaso, Miles MacLeod
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In Silico and In Vitro Analysis of MAP3773c Protein from Mycobacterium avium subsp. Paratuberculosis
Biology, 2022 Paratuberculosis is a disease caused by Mycobacterium avium subsp. paratuberculosis (MAP). It is of great interest to better understand the proteins involved in the pathogenicity of this organism in order to be able to identify potential therapeutic ...
Esteban Hernández-Guevara +10 more
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