Results 21 to 30 of about 170,795 (287)
Frontiers in Oncology, 2021 In silico models of biomolecular regulation in cancer, annotated with patient-specific gene expression data, can aid in the development of novel personalized cancer therapeutic strategies.
Mahnoor Naseer Gondal +11 more
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Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk
Cell Reports Medicine, 2020 Summary: There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of
Mark R. Davies +11 more
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Modeling Neurodegeneration in silico With Deep Learning [PDF]
Frontiers in Neuroinformatics, 2021 Deep neural networks, inspired by information processing in the brain, can achieve human-like performance for various tasks. However, research efforts to use these networks as models of the brain have primarily focused on modeling healthy brain function so far.
Anup Tuladhar +13 more
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The Scope and Limitations of In Vivo and In Silico Models of Cardiac Amyloidosis
Engineering Proceedings, 2023 Amyloidosis is a systemic disease, leading to the disfunction of many organs. There are several clinical and morphological forms of amyloidosis based on the organ-specific nature of amyloid fibril deposition, which is found in the heart, brain, kidneys ...
Svetlana Morozkina +2 more
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Critical Care Medicine, 2013 To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.PubMed search and review of relevant medical literature.Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole ...
Yoram, Vodovotz, Timothy R, Billiar
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, 2020 This dataset accompanies the manuscript: Ingram & Henthorn et al., Hi-C implementation of genome structure for in silico models of radiation-induced DNA damage. Each directory contains a corresponding About.txt file which details the contents of each
Mackay, Ranald +8 more
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The acceptance of
, 2011 In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes.
Antonio Cassano +31 more
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In silico models of cancer [PDF]
WIREs Systems Biology and Medicine, 2010 AbstractCancer is a complex disease that involves multiple types of biological interactions across diverse physical, temporal, and biological scales. This complexity presents substantial challenges for the characterization of cancer biology, and motivates the study of cancer in the context of molecular, cellular, and physiological systems ...
Lucas B, Edelman +2 more
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Experimental Models as Refined Translational Tools for Breast Cancer Research
Scientia Pharmaceutica, 2020 Breast cancer is one of the most common cancers worldwide, which makes it a very impactful malignancy in the society. Breast cancers can be classified through different systems based on the main tumor features and gene, protein, and cell receptors ...
Eduardo Costa +5 more
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