Results 71 to 80 of about 170,795 (287)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecules, 2022 Deep eutectic solvents (DES) are an important class of green solvents that have been developed as an alternative to toxic solvents. However, the large-scale industrial application of DESs requires fine-tuning their physicochemical properties.
Amit Kumar Halder +4 more
doaj +1 more source
Multiscale In Silico Modeling of Cartilage Injuries
, 2023 AbstractInjurious loading of the joint can be accompanied by articular cartilage damage and trigger inflammation. However, it is not well-known which mechanism controls further cartilage degradation, ultimately leading to post-traumatic osteoarthritis.
Eskelinen Atte Seppo Aleksi +5 more
openaire +2 more sources
Arrhythmia models: in vivo, in vitro and in silico [PDF]
Drug Discovery Today: Disease Models, 2009 Remodeling of ion channel and/or intracellular calcium handling properties lies at the heart of numerous congenital and acquired cardiovascular disorders that culminate in lethal arrhythmias. Typically pathophysiological remodeling is caused by a complex interplay between electrical, mechanical, structural, metabolic, and genetic alterations which ...
Fadi G, Akar, Colleen E, Clancy
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Journal of Orthopaedic TranslationEstablish alternative strategies to standard animal experiments decrease animal utilization and simultaneously enhance the reliability of biological and disease models.
Qi Gao +7 more
doaj +1 more source
Molecules, 2019 Phenols are the most abundant naturally accessible antioxidants present in a human normal diet. Since numerous beneficial applications of phenols as preventive agents in various diseases were revealed, the evaluation of phenols bioavailability is of high
Katja Venko, Marjana Novič
doaj +1 more source
Environment International, 2022 Alkylphenols (APs) are ubiquitous and generally present in higher residue levels in the environment. The present work focuses on the development of a set of in silico models to predict the aquatic toxicity of APs with incomplete/unknown toxicity data in ...
Yajun Hong +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source