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In Silico Models for Developmental Toxicity
2022Modeling developmental toxicity has been a challenge for (Q)SAR model developers due to the complexity of the endpoint. Recently, some new in silico methods have been developed introducing the possibility to evaluate the integration of existing methods by taking advantage of various modeling perspectives. It is important that the model user is aware of
Marco, Marzo +4 more
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In Silico Models for Hepatotoxicity
2016In this chapter we review the challenges of predicting human hepatotoxicity. Principally, this is our partial understanding of a very complex biochemical system and our ability to emulate that in a predictive capacity. We give an overview of the published modeling approaches in this area to date and discuss their design, strengths, and weaknesses.
Mark, Hewitt, Katarzyna, Przybylak
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In silico modelling of physiologic systems
Best Practice & Research Clinical Anaesthesiology, 2011In silico modelling, in which computer models are developed to model a pharmacologic or physiologic process, is a logical extension of controlled in vitro experimentation. It is the natural result of the explosive increase in computing power available to the research scientist at continually decreasing cost.
Richard B, Colquitt +2 more
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In Silico Modeling of Crabtree Effect
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2017Glycolytic activity during Crabtree effect is similar to that in tumor cells. Research regarding Crabtree effect is very much crucial.The mechanism of metabolic activities in glycolysis pathway and oxidative phosphorylation pathway in regards to Crabtree effect in Saccharomyces cerevisiae was studied in this paper.
Debraj, Ghosh, Rajat K, De
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A Hyperneuron Model Towards in Silico Implementation
International Journal of Bifurcation and Chaos, 2022In this paper, the concept of hyperneuron is introduced. The main properties and dynamical characteristics of this class of hypersystems will be studied by numerical analysis. The intrinsic robustness of the proposed model is further investigated by proposing a silicon implementation of the hyperneuron, reporting the corresponding experimental results.
Branciforte M., Buscarino A., Fortuna L.
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Towards in silico Process Modeling for Vaccines
Trends in Biotechnology, 2021Chemical, manufacturing, and control development timelines occupy a significant part of vaccine end-to-end development. In the on-going race for accelerating timelines, in silico process development constitutes a viable strategy that can be achieved through an artificial intelligence (AI)-driven or a mechanistically oriented approach.
Antonio Gaetano, Cardillo +9 more
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In Silico Blood Pressure Models Comparison
IEEE Sensors Journal, 2022As cardiovascular diseases (CVDs) are one of the most prominent illnesses, continuous, noninvasive, and comfortable monitoring of blood pressure (BP) is indispensable. This article investigates the best method for obtaining highly accurate BP values in noninvasive measurements through the extraction of hemodynamic variables from the arteries of young ...
Ana Carolina Goncalves Seabra +3 more
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In Silico Models for Skin Sensitization and Irritation
2022The assessment of skin irritation, and in particular of skin sensitization, has undergone an evolution process over the last years, pushing forward to new heights of quality and innovation. Public and commercial in silico tools have been developed for skin sensitization and irritation, introducing the possibility to simplify the evaluation process and ...
Gianluca, Selvestrel +2 more
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Evolution in Silico and in Vitro: The RNA Model
Biological Chemistry, 2001Theoretical concepts and experiments dealing with the evolution of molecules in vitro reached a state that allows for direct applications to the design of biomolecules with predefined properties. RNA evolution in vitro represents a basis for the development of a new and comprehensive model of evolution, focusing on the phenotype and its fitness ...
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Metabolic modeling of microbial strains in silico
Trends in Biochemical Sciences, 2001The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of ...
M W, Covert +6 more
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