Results 261 to 270 of about 170,795 (287)
Some of the next articles are maybe not open access.
In Silico Models for Skin Sensitization and Irritation
2022The assessment of skin irritation, and in particular of skin sensitization, has undergone an evolution process over the last years, pushing forward to new heights of quality and innovation. Public and commercial in silico tools have been developed for skin sensitization and irritation, introducing the possibility to simplify the evaluation process and ...
Gianluca, Selvestrel +2 more
openaire +2 more sources
Evolution in Silico and in Vitro: The RNA Model
Biological Chemistry, 2001Theoretical concepts and experiments dealing with the evolution of molecules in vitro reached a state that allows for direct applications to the design of biomolecules with predefined properties. RNA evolution in vitro represents a basis for the development of a new and comprehensive model of evolution, focusing on the phenotype and its fitness ...
openaire +3 more sources
IN SILICO MODELS OF ACUTE INFLAMMATION IN ANIMALS
Shock, 2006Trauma and hemorrhagic shock elicit an acute inflammatory response, predisposing patients to sepsis, organ dysfunction, and death. Few approved therapies exist for these acute inflammatory states, mainly due to the complex interplay of interacting inflammatory and physiological elements working at multiple levels.
Yoram, Vodovotz +12 more
openaire +2 more sources
Metabolic modeling of microbial strains in silico
Trends in Biochemical Sciences, 2001The large volume of genome-scale data that is being produced and made available in databases on the World Wide Web is demanding the development of integrated mathematical models of cellular processes. The analysis of reconstructed metabolic networks as systems leads to the development of an in silico or computer representation of collections of ...
M W, Covert +6 more
openaire +2 more sources
In Silico Modelling of Pesticide Aquatic Toxicity
Combinatorial Chemistry & High Throughput Screening, 2014Human activities have introduced tens of thousands of chemicals into water systems around the world which has significantly impacted water quality and aquatic ecosystems. The aim of this study was to develop an in silico QSAR model, capable of predicting the aquatic toxicity of pesticides in terms of a lethal dose (LD50) for fish without requiring the ...
Agatonović-Kuštrin, Snežana +2 more
openaire +4 more sources
In Silico Models for Acute Systemic Toxicity
2016In this chapter, we give an overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review the availability of structure-based computational models that are available and potentially useful in the assessment of acute systemic toxicity. The most recently published literature models for acute systemic
Julien, Burton +3 more
openaire +2 more sources
In silico modelling--pharmacophores and hERG channel models.
Novartis Foundation symposium, 2005In computational drug design, modelling studies are undertaken following two main strategies that depend on which information is available. If experimental data exist only for the molecules displaying the biological property of interest, a so-called ligand-based approach is taken; if information is available on the macromolecular target(s) of the ...
RECANATINI, MAURIZIO +2 more
openaire +2 more sources