Results 221 to 230 of about 114,349,436 (308)

In Silico Prediction of Tetrastatin-Derived Peptide Interactions with αvβ3 and α5β1 Integrins. [PDF]

Pharmaceuticals (Basel)
Paturel V, Baud S, Schneider C, Brassart-Pasco S.   +3 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Routine RNA-based analysis of potential splicing variants facilitates genomic diagnostics and reveals limitations of in silico prediction tools. [PDF]

HGG Adv
Drost M, Dekker J, Ferraro F, Kasteleijn E, Verschuren M, Kroon E, Douben HCW, Vogt I, van Unen L, Hoogeveen-Westerveld M, Elfferich P, Schot R, Calandrini C, Korpershoek E, Sleutels F, Brüggenwirth HBR, Hollink IR, Meerstein-Kessel L, Hoefsloot LH, van Slegtenhorst M, Wilke M, Weerts MJA, van Minkelen R, Wagner A, Bouman A, van Paassen BW, Verheijen-Mancini GM, van de Laar IMBH, Kievit AJA, Verhagen JMA, Stuurman KE, Donker Kaat L, van Dooren MF, Wessels MW, Oldenburg RA, Zeidler S, van Dijk T, Barakat TS, Verhoeven VJM, van Bever Y, van Ierland Y, Bannink N, van Koningsbruggen S, Lakeman P, Leeuwen L, Verbeek NE, Sinnema M, Heijligers M, van Asperen CJ, Saris JJ, Nellist M, van Ham TJ.   +51 more
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Identification of silibinin and isotretinoin as potent up-regulators of sFRP4 (Wnt antagonist): In silico prediction and in vitro validation in breast cancer. [PDF]

PLoS One
Ramzan R, Bukhari SA, Rasul A.
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

In silico prediction method for plant Nucleotide-binding leucine-rich repeat- and pathogen effector interactions. [PDF]

Plant J
Fick A, Fick JLM, Swart V, van den Berg N.   +3 more
europepmc   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

In silico prediction of GRP78-CRIPTO binding sites to improve therapeutic targeting in glioblastoma. [PDF]

Sci Rep
Rashwan ME, Ahmed MR, Elfiky AA.
europepmc   +1 more source

Machine‐Learning‐Assisted Impedance Component Analysis Enables Standardizable Surface Protein Analysis of Extracellular Vesicles Using Engineered Nanovesicles

Advanced Science, EarlyView.
This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song, Neethu Ramakrishnan, Sehyeon Kim, Huiseop Lee, Youngeun Kwon, Jinsik Kim   +5 more
wiley   +1 more source