Results 281 to 290 of about 114,349,436 (308)
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In silico methods to predict drug toxicity
Current Opinion in Pharmacology, 2013This review describes in silico methods to characterize the toxicity of pharmaceuticals, including tools which predict toxicity endpoints such as genotoxicity or organ-specific models, tools addressing ADME processes, and methods focusing on protein-ligand docking binding. These in silico tools are rapidly evolving.
Alessandra, Roncaglioni +3 more
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Predicting the Occurrence of Sepsis by In Silico Simulation
2014From public health and clinical point of view, sepsis is a life-threatening complication and its mechanisms are still not fully understood. This article claims that Multiagent Systems are suitable to help elucidate this phenomenon and that it is possible to carry out simulations that can be used in the observation of emergent behaviors, enabling a ...
Flávio Oliveira de Sousa +5 more
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An overview of in silico protein function prediction
Archives of Microbiology, 2010As the protein databases continue to expand at an exponential rate, fed by daily uploads from multiple large scale genomic and metagenomic projects, the problem of assigning a function to each new protein has become the focus of significant research interest in recent times.
Roy D, Sleator, Paul, Walsh
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In Silico Tools for Predicting Novel Epitopes
Identifying antigens within a pathogen is a critical task to develop effective vaccines and diagnostic methods, as well as understanding the evolution and adaptation to host immune responses. Historically, antigenicity was studied with experiments that evaluate the immune response against selected fragments of pathogens.Barra, Carolina +11 more
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In Silico Approaches in Predictive Genetic Toxicology
In silico toxicology methods facilitate clear interpretation of the observed experimental genetic toxicity trends and provide faster, more economical, and animal-free tools for the benefit of environmental and human health in conjunction with other relevant in vitro and in vivo methods.Meetali, Sinha +3 more
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In silico prediction of post-translational modifications in therapeutic antibodies
MAbs, 2022Shabdita Vatsa
exaly
In Silico Prediction of Target-Inhibitor Interaction
2015For a long time people are trying to predict interactions of molecules. The base for this is always a 3D structure of both partners. Based on the increasing numbers of X-Ray structures of proteins with and without bounded molecules algorithms were developed to predict the target-inhibitor interaction based on known structures of proteins.
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In silico prediction of toxicity and its applications for chemicals at work
Toxicology and Environmental Health Sciences, 2020Kyung-Taek Rim
exaly
In Silico Approaches for the Prediction and Analysis of Antiviral Peptides: A Review
Current Pharmaceutical Design, 2021Nuttapat Anuwongcharoen +2 more
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