Results 191 to 200 of about 16,993 (213)

Yak milk casein as potential precursor of angiotensin I-converting enzyme inhibitory peptides based on in silico proteolysis

Food Chemistry, 2018
Yak milk casein was selected as a potential precursor of bioactive peptides based on in silico analysis. Most notable among these are the angiotensin I-converting enzyme (ACE) inhibitory peptides. First, yak milk casein has high homology with cow milk casein by homologous analysis.
Kai Lin, Xue Han, Liang Xin
exaly   +3 more sources

RETRACTED: In silico proteolysis and molecular interaction of tilapia (Oreochromis niloticus) skin collagen-derived peptides for environmental remediation

Environmental Research, 2022
Fish skin collagen hydrolyzate has demonstrated the potent inhibition of dipeptidyl peptidase-IV (DPP-IV), one of the treatments for type-2 diabetes mellitus (type-2 DM), but the precise mechanism is still unclear. This study used in silico method to evaluate the potential of the active peptides from tilapia skin collagen (Oreochromis niloticus) for ...
Heli Siti Halimatul Munawaroh, Gun Gun Gumilar, Jerlita Dea Berliana, Siti Aisyah, Vidia Afina Nuraini, Andriati Ningrum, Eko Susanto, Larasati Martha, Isman Kurniawan, Nur Akmalia Hidayati, Apurav Krishna Koyande, Pau-Loke Show   +11 more
openaire   +3 more sources

Initial proteolysis of milk proteins and its effect on formation of ACE-inhibitory peptides during gastrointestinal proteolysis: a bioinformatic, in silico, approach

European Food Research and Technology, 2005
Angiotensin-I-converting enzyme (ACE)-inhibitory peptides are encrypted in milk protein sequences. They may express an antihypertensive effect if they are released by proteolysis in foods and/or during gastrointestinal digestion. A bioinformatic, in silico, approach was developed to evaluate how systematic initial proteolysis, i.e.
exaly   +3 more sources

Computational methods and key considerations for in silico design of proteolysis targeting chimera (PROTACs)

International Journal of Biological Macromolecules
Proteolysis-targeting chimeras (PROTACs), as heterobifunctional molecules, have garnered significant attention for their ability to target previously undruggable proteins. Due to the challenges in obtaining crystal structures of PROTAC molecules in the ternary complex, a plethora of computational tools have been developed to aid in PROTAC design. These
Amr, Abbas, Fei, Ye
exaly   +3 more sources

In silico methods to identify ACE and DPP-IV inhibitory activities of ribosomal hazelnut proteins [PDF]

Journal of Food Measurement and Characterization, 2018
WOS: 000452363700039In this study, an in silico attempt was made to evaluate the biological functionality of hazelnut (Corylus avellana L.) peptides, using three gastrointestinal (GI) and three non-GI enzymes. As of March 2017, 469 hazelnut proteins were
Ibrahim Gülseren
exaly   +2 more sources

In silico analysis of amino acid biosynthesis and proteolysis in Lactobacillus delbrueckii subsp. bulgaricus 2038 and the implications for bovine milk fermentation

Biotechnology Letters, 2012
The amino acid biosynthesis pathway and proteolytic system of Lactobacillus delbrueckii subsp. bulgaricus 2038 (L. bulgaricus 2038), a mainstay of large-scale yogurt production, were modeled based on its genomic sequence. L. bulgaricus 2038 retains more potential for amino acid synthesis and a more powerful proteolytic system than other L.
Huajun, Zheng, Enuo, Liu, Pei, Hao, Tomonobu, Konno, Munehiro, Oda, Zai-Si, Ji   +5 more
openaire   +2 more sources

Dynamic characteristics of proteolysis-targeting chimera systems revealed by in silico computations

Current Opinion in Structural Biology
Proteolysis-targeting chimeras (PROTACs) achieve irreversible clearance of target proteins by hijacking the ubiquitin-proteasome system, breaking the design paradigm of traditional inhibitory drugs. The development of computational approaches has effectively promoted the rational design of PROTACs, yet existing methods mainly focus on predicting the ...
Kexin Xu, Jingxuan Ge, Rongfan Tang, Tingjun Hou, Huiyong Sun   +4 more
openaire   +2 more sources

Discovery of hPRDX5-based peptide inhibitors blocking PD-1/PD-L1 interaction through in silico proteolysis and rational design

Cancer Chemotherapy and Pharmacology, 2019
The human peroxiredoxin-5 (hPRDX5) is a member of the family of antioxidant enzymes, which could resist immunosuppression by promoting immune organs development, lymphocyte proliferation and up-regulation of the levels of serum cytokines. However, being a recombinant protein, the hPRDX5 exhibits some problems including the high production cost and bad ...
Sen, Zou, Juanjuan, Liu, Zhengyang, Sun, Xiao, Feng, Zhongbo, Wang, Yuanyuan, Jin, Zhaoyong, Yang   +6 more
openaire   +2 more sources

In Silico Screening for Small Molecules to Alter Calpain Proteolysis through Modulating Conformation Changes Induced by Heterodimerization

Journal of Chemical Information and Modeling
Dysregulated calpain-1 and calpain-2 protease activity linked to several diseases has encouraged efforts to explore inhibiting calpain to provide therapeutic benefits. However, there are currently no clinically approved drugs that specifically target calpain functionality.
Pitambar Poudel, Ivan Shapovalov, Shailesh Kumar Panday, Kazem Nouri, Peter L. Davies, Peter A. Greer, Emil Alexov   +6 more
openaire   +2 more sources

[Pharmacological mechanism analysis of oligopeptide from Pinctada fucata based on in silico proteolysis and protein interaction network].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
Pinctada fucata oligopeptide is one of key pharmaceutical effective constituents of P. fucata. It is significant to analyze its pharmacological effect and mechanism. This study aims to discover the potential oligopeptides from P. fucata and analyze the mechanism of P.
Yan-Kun, Chen, Lian-Sheng, Qiao, Xiao-Qian, Huo, Xu, Zhang, Na, Han, Yan-Ling, Zhang   +5 more
openaire   +3 more sources