Results 181 to 190 of about 16,756 (205)

Ceftibuten-polymyxin B combination alters resistance and cell wall gene expression in multidrug-resistant Klebsiella pneumoniae. [PDF]

PLoS One
Sturaro MC, Silva RCCD, Simionatto S.
europepmc   +1 more source

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Yak milk casein as potential precursor of angiotensin I-converting enzyme inhibitory peptides based on in silico proteolysis

Food Chemistry, 2018
Yak milk casein was selected as a potential precursor of bioactive peptides based on in silico analysis. Most notable among these are the angiotensin I-converting enzyme (ACE) inhibitory peptides. First, yak milk casein has high homology with cow milk casein by homologous analysis.
Xue Han, Kai Lin
exaly   +3 more sources

Initial proteolysis of milk proteins and its effect on formation of ACE-inhibitory peptides during gastrointestinal proteolysis: a bioinformatic, in silico, approach

European Food Research and Technology, 2005
Angiotensin-I-converting enzyme (ACE)-inhibitory peptides are encrypted in milk protein sequences. They may express an antihypertensive effect if they are released by proteolysis in foods and/or during gastrointestinal digestion. A bioinformatic, in silico, approach was developed to evaluate how systematic initial proteolysis, i.e.
exaly   +3 more sources

Computational methods and key considerations for in silico design of proteolysis targeting chimera (PROTACs)

International Journal of Biological Macromolecules
Proteolysis-targeting chimeras (PROTACs), as heterobifunctional molecules, have garnered significant attention for their ability to target previously undruggable proteins. Due to the challenges in obtaining crystal structures of PROTAC molecules in the ternary complex, a plethora of computational tools have been developed to aid in PROTAC design. These
Amr, Abbas, Fei, Ye
exaly   +3 more sources

Dynamic characteristics of proteolysis-targeting chimera systems revealed by in silico computations

Current Opinion in Structural Biology
Proteolysis-targeting chimeras (PROTACs) achieve irreversible clearance of target proteins by hijacking the ubiquitin-proteasome system, breaking the design paradigm of traditional inhibitory drugs. The development of computational approaches has effectively promoted the rational design of PROTACs, yet existing methods mainly focus on predicting the ...
Tingjun Hou, Huiyong Sun
exaly   +3 more sources

RETRACTED: In silico proteolysis and molecular interaction of tilapia (Oreochromis niloticus) skin collagen-derived peptides for environmental remediation

Environmental Research, 2022
Fish skin collagen hydrolyzate has demonstrated the potent inhibition of dipeptidyl peptidase-IV (DPP-IV), one of the treatments for type-2 diabetes mellitus (type-2 DM), but the precise mechanism is still unclear. This study used in silico method to evaluate the potential of the active peptides from tilapia skin collagen (Oreochromis niloticus) for ...
Heli Siti Halimatul Munawaroh, Gun Gun Gumilar, Jerlita Dea Berliana, Siti Aisyah, Vidia Afina Nuraini, Andriati Ningrum, Eko Susanto, Larasati Martha, Isman Kurniawan, Nur Akmalia Hidayati, Apurav Krishna Koyande, Pau-Loke Show   +11 more
openaire   +2 more sources

In silico analysis of amino acid biosynthesis and proteolysis in Lactobacillus delbrueckii subsp. bulgaricus 2038 and the implications for bovine milk fermentation

Biotechnology Letters, 2012
The amino acid biosynthesis pathway and proteolytic system of Lactobacillus delbrueckii subsp. bulgaricus 2038 (L. bulgaricus 2038), a mainstay of large-scale yogurt production, were modeled based on its genomic sequence. L. bulgaricus 2038 retains more potential for amino acid synthesis and a more powerful proteolytic system than other L.
Huajun, Zheng, Enuo, Liu, Pei, Hao, Tomonobu, Konno, Munehiro, Oda, Zai-Si, Ji   +5 more
openaire   +2 more sources

Discovery of hPRDX5-based peptide inhibitors blocking PD-1/PD-L1 interaction through in silico proteolysis and rational design

Cancer Chemotherapy and Pharmacology, 2019
The human peroxiredoxin-5 (hPRDX5) is a member of the family of antioxidant enzymes, which could resist immunosuppression by promoting immune organs development, lymphocyte proliferation and up-regulation of the levels of serum cytokines. However, being a recombinant protein, the hPRDX5 exhibits some problems including the high production cost and bad ...
Sen, Zou, Juanjuan, Liu, Zhengyang, Sun, Xiao, Feng, Zhongbo, Wang, Yuanyuan, Jin, Zhaoyong, Yang   +6 more
openaire   +2 more sources