Results 61 to 70 of about 114,934,872 (306)

In situ hybridization

Molecular and Cellular Probes, 1987
In situ hybridization is the hybridization-mediated detection of specific nucleic acid sequences within structurally intact cells or tissues. As such it uniquely provides localization of nucleic acid superimposed on observable cellular and subcellular structural detail, allowing analysis unobtainable by other hybridization techniques.
openaire   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Study on mechanics and permeability evolution of sandy mudstone during full stress-strain loading

Meitan xuebao
The evolution law of surrounding rock pore crack and its permeability change during soft rock roadway excavation is one of the basic scientific problems to be solved in water inrush disaster prevention and grouting reinforcement of weak surrounding rock.
Zhaoyun CHAI, Xiaoling WU, Xiangyu LIU, Xu LIU, Yuxu SHEN, Zipeng XIN   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Architecture and Nation. The Schleswig Example, in comparison to other European Border Regions [PDF]

, 2019
Looking back at the five analyzed border regions, one might conclude that the relations between nation and nationality on one hand and architecture on the other hand demonstrate interesting similarities and differences.
Dragsbo, Peter, Peter Dragsbo
core   +1 more source

Mechanism of Fracture Evolution and the Mechanical Response of Coal Rock Composites

Applied Sciences
Understanding the mechanism of fracture evolution in underground stacked coal–rock composite structures is crucial for the accurate prediction and prevention of mine disasters.
Fengqi Guo, Weiguo Liang, Shengli Zhang, Wei He, Yongjun Yu, Zehan Zhang   +5 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

The bed from the castle of Effiat in the Louvre museum [PDF]

, 2019
The bed which originally came from the Effiat chateau in the Puy-de-Dôme department and which is presented today in the Louvre, in the rooms of the department devoted to art objects, is well known as one of the rare surviving examples of a ‘French-style’
Agnès Bos, Bos, Agnès
core   +1 more source

DeBCR: a sparsity-efficient framework for image enhancement through a deep-learning-based solution to inverse problems

Communications Engineering
Computational image enhancement for microscopy facilitates cutting-edge biological discovery. While promising, the commonly used deep learning methods are computationally expensive owing to the use of general-purpose architectures, which are inefficient ...
Rui Li, Artsemi Yushkevich, Xiaofeng Chu, Mikhail Kudryashev, Artur Yakimovich   +4 more
doaj   +1 more source