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Fluorescence In situ Hybridization
1996During the last decade, pathology has progressed remarkably with the incorporation of molecular techniques into the arena of diagnostics. Fluorescence in situ hybridization (FISH) is a molecular histopathological technique that can be readily used to identify DNA or RNA abnormalities at the cellular level with the use of an epifluorescence microscope ...
Victoria Belogolovkin +6 more
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Fluorescent In Situ Hybridization
2001Fluorescence in situ hybridization (FISH) arose from a marriage of classical DNA hybridization in solution to modern molecular biologic techniques, most notably the use of restriction endonucleases and, later, the polymerase chain reaction (PCR). The former has made identification of both genes and relevant interspersed sequences possible, whereas ...
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Raman-Fluorescence in Situ Hybridization
2014As with many other molecular microbiology methods, the family of stable isotope probing (SIP) techniques based on the analysis of isotope- labeled nucleic acids, phospholipid fatty acids (PLFAs), or proteins are frequently performed at the level of the community.
Read, Daniel, Whiteley, Andrew
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Fluorescence In Situ Hybridization (
AbstractFluorescence in situ Hybridization (FISH) involves the preparation of two main components: the DNA probe and the target DNA to which the probe will be hybridized. The DNA probe typically comes from cloned sources such as plasmids, cosmids, PACs, YACs, or BACs; where the insert may contain a specific gene or originate from a specific chromosomal
Jeremy A. Squire, Jane Bayani
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Blaming the Right Fluorescent in Situ Hybridization
Journal of Clinical Oncology, 2015TO THE EDITOR: Bochtler et al have observed that patients with light chain (AL) amyloidosis with t(11;14) fare worse with bortezomib-based therapy. This observation is difficult to reconcile given both the fact that a majority of patients with AL have t(11;14), and that bortezomib has been observed to be a highly effective therapy in patients with AL ...
Angela Dispenzieri, Rahma Warsame
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Advances in fluorescence in situ hybridization
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998The techniques of in situ hybridization (ISH) are widely applied for analyzing the genetic make-up and RNA expression patterns of individual cells. This review focusses on a number of advances made over the last 5 years in the fluorescence ISH (FISH) field, i.e., Fiber-FISH, Multi-colour chromosome painting, Comparative Genomic Hybridization, Tyramide ...
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Fluorescence in situ hybridization: A brief review
Environmental and Molecular Mutagenesis, 1996Fluorescence in situ hybridization (FISH) is used for many purposes, including analysis of chromosomal damage, gene mapping, clinical diagnostics, molecular toxicology and cross-species chromosome homology. FISH allows an investigator to identify the presence and location of a region of cellular DNA or RNA within morphologically preserved chromosome ...
Roy R. Swiger, James D. Tucker
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Fluorescence in situ Hybridization in Cytopathology
2020The application of ancillary studies to small biopsies and cytopathology specimens has been increasing for definitive diagnoses and theranostic information. Fluorescence in situ hybridization (FISH) is one of the ancillary techniques being applied to these small specimens, and has been utilized with great success for years, particularly in the ...
Sanja Dacic, Sara E. Monaco
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Fluorescence In Situ Hybridization and Comparative Genomic Hybridization
2006This chapter discusses the complementary methodologies of fluorescence in situ hybridization and comparative genomic hybridization. Fluorescence in situ hybridization uses fluorescently labeled DNA probes (whole chromosomes, centromere, or locus-specific sequences) to visualize complementary DNA sequences in the target DNA (metaphase chromosomes or ...
Patricia Gorman, Rebecca Roylance
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Fluorescence In Situ Hybridization
2001There is a rumor that goes like this: After a particularly successful day at an international genetics conference in the late 1960s in Scotland, delegates rewarded themselves with the customary pint of beer at their favorite watering hole, the public house.
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