Results 181 to 190 of about 2,554,686 (233)

Polymeric microcontainers improve oral bioavailability of a poorly soluble drug [PDF]

open access: yes, 2015
Boisen, Anja   +5 more
core  

Intestinal Absorption by Perfusion in Situ

open access: closedJournal of Applied Physiology, 1957
An apparatus and technique for the perfusion of a specific cannulated segment of small intestine of the rat, in situ, have been described. By the removal and analysis of perfusate samples from the system, continuous intestinal absorption curves have been established from a single animal in the steady state.
Francis A. Jacobs, Miltza Luper
openalex   +4 more sources

Intestinal Permeability of Forskolin byIn SituSingle Pass Perfusion in Rats

open access: closedPlanta Medica, 2012
The intestinal permeability of forskolin was investigated using a single pass intestinal perfusion (SPIP) technique in rats. SPIP was performed in different intestinal segments (duodenum, jejunum, ileum, and colon) with three concentrations of forskolin (11.90, 29.75, and 59.90 µg/mL).
Zhenjun Liu   +5 more
openalex   +3 more sources

Circadian Variations in Exsorptive Transport: In Situ Intestinal Perfusion Data and In Vivo Relevance

open access: closedChronobiology International, 2012
The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics. P-glycoprotein (P-gp) is a drug transporter that plays a pivotal role in drug absorption, distribution, and elimination, and temporal changes in its activity may affect input, output, activity, and toxicity ...
Alper Okyar   +5 more
openalex   +4 more sources

Simultaneous determination of digoxin and permeability markers in rat in situ intestinal perfusion samples by RP-HPLC

open access: closedJournal of Chromatography B, 2004
A simple, sensitive and specific reversed-phase high performance liquid chromatographic (RP-HPLC) assay for simultaneous determination of digoxin and permeability markers, in samples obtained from intestinal in situ single-pass perfusion studies, was developed and validated.
Manthena V. S. Varma   +3 more
openalex   +4 more sources

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