Results 191 to 200 of about 2,554,686 (233)
Journal of Asian Natural Products Research, 2017 The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaë rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and ...
Lei Xin +6 more
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Journal of Pharmaceutical Sciences, 2009 LY354740 is a potent mGlu2/3 agonist with a limited oral bioavailability. Its alanyl prodrug, LY544344, showed high affinity to the intestinal peptide transporter PEPT1, and improved the oral bioavailability of LY354740 in various animal models. The aim of the present study was to investigate the mechanism of in vivo absorption of the dipeptidic ...
André Huss Eriksson +3 more
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Transplantation Proceedings, 2009 The main purpose of the present investigation was to describe a model of intestinal denervation and in situ intestinal ischemia-reperfusion injury in adult rats, with utilization of the distal branch of the superior mesenteric artery close to the cecum for perfusion.In the root of the mesentery, the mesenteric artery and vein were completely isolated ...
Maria Mercês Santos +3 more
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Optimal Perfusion Rate Determined for In Situ Intestinal Absorption Studies in Rats
Journal of Pharmaceutical Sciences, 1981Iopanoic acid was used as a model compound to study the effect of the intestinal perfusion rate on the mean absorption clearance. Absorption of iopanoic acid followed first-order kinetics, with a first-order absorption rate constant (ka) linearly dependent on the dry intestinal weight. An absorption clearance--time plot revealed three phases.
Paul M. Savina +3 more
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Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.
Drug Metabolism and Disposition, 1986The in situ perfused rat small intestine preparation was used to examine the extents of segmental absorption and metabolism of acetaminophen (A). Additionally, the preparation was employed to investigate any intestinal excretion of A and its conjugates from the circulation to the intestinal lumen.
K S, Pang +4 more
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Intestinal Absorption of γ-Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies [PDF]
Drug Metabolism and Disposition, 2010 gamma-Tocotrienol (gamma-T3) is a member of the vitamin E family that displays potent anticancer activity and other therapeutic benefits. The objective of this study was to evaluate gamma-T3 intestinal uptake and metabolism using the in situ rat intestinal perfusion model. Isolated segments of rat jejunum and ileum were perfused with gamma-T3 solution,
Paul W. Sylvester +2 more
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Drug Metabolism and Disposition, 1993
Carbovir (CBV), a carbocyclic nucleoside analog, is a potent and selective inhibitor of human immunodeficiency virus in human T-cells at noncytotoxic concentrations. Previous pharmacokinetic studies of (-)CBV in the rat showed nonlinearity in both the renal and nonrenal clearances and an oral bioavailability of 20%.
I, Soria, C L, Zimmerman
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Carbovir (CBV), a carbocyclic nucleoside analog, is a potent and selective inhibitor of human immunodeficiency virus in human T-cells at noncytotoxic concentrations. Previous pharmacokinetic studies of (-)CBV in the rat showed nonlinearity in both the renal and nonrenal clearances and an oral bioavailability of 20%.
I, Soria, C L, Zimmerman
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China Journal of Chinese Materia Medica, 2011
To study the absorption characteristics of alkaloids in Coptis chinensis in rat intestinal.In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC, the drug absorption rate constant (K(a)) and apparent absorption coefficient (P(app)) were tested to evaluate their absorption ...
Lijuan Zou +7 more
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To study the absorption characteristics of alkaloids in Coptis chinensis in rat intestinal.In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC, the drug absorption rate constant (K(a)) and apparent absorption coefficient (P(app)) were tested to evaluate their absorption ...
Lijuan Zou +7 more
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Absorption of Hydroxyproline-Containing Peptides in Vascularly Perfused Rat Small Intestinein Situ
Bioscience, Biotechnology, and Biochemistry, 2009To assess the digestion and assimilation of gelatin and gelatin hydrolysates, the in situ absorption of typical hydroxyproline-containing dipeptides, Pro-Hyp, Hyp-Gly, Ser-Hyp Ala-Hyp, and pentadecapeptide, (Pro-Hyp-Gly)(5), was investigated in the rat small intestine.
Chinfang Liu +5 more
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Mini-Reviews in Medicinal Chemistry, 2017
In 1995, the Biopharmaceutics Classification System (BCS) was proposed by Amidon and colleagues as a tool that considers two important parameters regarding drugs: solubility and permeability. Since then, several methods for solubility and permeability studies have been developed for drug delivery and absorption prediction. In recent years, permeability
Thaisa Marinho Dezani +3 more
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In 1995, the Biopharmaceutics Classification System (BCS) was proposed by Amidon and colleagues as a tool that considers two important parameters regarding drugs: solubility and permeability. Since then, several methods for solubility and permeability studies have been developed for drug delivery and absorption prediction. In recent years, permeability
Thaisa Marinho Dezani +3 more
openaire +3 more sources