Results 201 to 210 of about 2,554,686 (233)
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2017
To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater ...
Xue-Lian Li +6 more
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To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater ...
Xue-Lian Li +6 more
openaire +3 more sources
Drug Metabolism and Disposition, 2010
Darunavir is a second-generation protease inhibitor designed to have antiviral efficacy against HIV-1 with multiple resistance mutations to protease inhibitors. It is always coadministered with a subtherapeutic dose of ritonavir. It has been shown that darunavir and ritonavir are substrates of P-glycoprotein (P-gp). We explored the contribution of P-gp
Patrick Augustijns +3 more
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Darunavir is a second-generation protease inhibitor designed to have antiviral efficacy against HIV-1 with multiple resistance mutations to protease inhibitors. It is always coadministered with a subtherapeutic dose of ritonavir. It has been shown that darunavir and ritonavir are substrates of P-glycoprotein (P-gp). We explored the contribution of P-gp
Patrick Augustijns +3 more
openaire +3 more sources
Chinese Journal of Natural Medicines, 2014
To investigate the absorption characteristics of the total alkaloids from Mahoniae Caulis (TAMC) through the administration of monterpene absorption enhancers or protein inhibitors.The absorption behavior was investigated in an in situ single-pass intestinal perfusion (SPIP) assay in rats.The intestinal absorption of TAMC was much more than that of a ...
Chun-Feng Zhang +8 more
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To investigate the absorption characteristics of the total alkaloids from Mahoniae Caulis (TAMC) through the administration of monterpene absorption enhancers or protein inhibitors.The absorption behavior was investigated in an in situ single-pass intestinal perfusion (SPIP) assay in rats.The intestinal absorption of TAMC was much more than that of a ...
Chun-Feng Zhang +8 more
openaire +3 more sources
Drug Metabolism and Disposition, 2011
Intestinal absorption of temocapril, a prodrug of temocaprilat, was evaluated in an in situ rat jejunal perfusion model under various conditions of luminal pH and in the presence and absence of carboxylesterase-mediated hydrolysis. Temocapril was more easily taken up by mucosal cells at a luminal pH of 5.4 than at pH 6.4 or 7.4 and was extensively ...
Takaaki Nozawa, Teruko Imai
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Intestinal absorption of temocapril, a prodrug of temocaprilat, was evaluated in an in situ rat jejunal perfusion model under various conditions of luminal pH and in the presence and absence of carboxylesterase-mediated hydrolysis. Temocapril was more easily taken up by mucosal cells at a luminal pH of 5.4 than at pH 6.4 or 7.4 and was extensively ...
Takaaki Nozawa, Teruko Imai
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New Zealand Veterinary Journal, 2005
To develop an in situ animal model for assessing absorption of molecules across the intestinal mucosa of possums.A surgical preparation was used to perfuse known concentrations of reference compounds (fluorescein and luteinising hormone-releasing hormone; LHRH) through measured sections of selected regions (jejunum, caecum, proximal colon) of the ...
Ian G. Tucker +5 more
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To develop an in situ animal model for assessing absorption of molecules across the intestinal mucosa of possums.A surgical preparation was used to perfuse known concentrations of reference compounds (fluorescein and luteinising hormone-releasing hormone; LHRH) through measured sections of selected regions (jejunum, caecum, proximal colon) of the ...
Ian G. Tucker +5 more
openaire +3 more sources
Biopharmaceutics & Drug Disposition, 2019
AbstractAffecting the absorption of active ingredients in the intestine serves as one of the important compatibility mechanisms of traditional Chinese medicine. The aim of this study was to investigate the compatibility mechanism of ShengDiHuang Decoction (SDHD) by using the single‐pass intestinal perfusion in situ model.
Hui Yang +6 more
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AbstractAffecting the absorption of active ingredients in the intestine serves as one of the important compatibility mechanisms of traditional Chinese medicine. The aim of this study was to investigate the compatibility mechanism of ShengDiHuang Decoction (SDHD) by using the single‐pass intestinal perfusion in situ model.
Hui Yang +6 more
openaire +3 more sources
Absorption and metabolism of catechin after in-situ perfusion in the small intestine of rats
2000International ...
Donovan, J. +6 more
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1987
In calcium stone patients, total urinary calcium is decreased after oral alkali citrate (1). The mechanisms of this action are speculative, since the amount of oral citrate entering the organism by absorption is not known. Also, possible direct interactions between intraluminal calcium (Ca) and citrate, based for example on complex formation (2), and ...
G. Rümenapf +3 more
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In calcium stone patients, total urinary calcium is decreased after oral alkali citrate (1). The mechanisms of this action are speculative, since the amount of oral citrate entering the organism by absorption is not known. Also, possible direct interactions between intraluminal calcium (Ca) and citrate, based for example on complex formation (2), and ...
G. Rümenapf +3 more
openaire +2 more sources
In Situ Single Pass Perfused Rat Intestinal Model
2013Maria Markowska, L. Mark Kao
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