Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò +18 more
wiley +1 more source
Identification, biotransformation, and neuroprotective potential of the ethanol extract of <i>Alpiniae oxyphyllae</i> fructus in neuroinflammation-related cognitive impairment. [PDF]
Yi Z +13 more
europepmc +1 more source
Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem +9 more
wiley +1 more source
Meta-analysis of levamisole absorption and disposition across diverse species using a minimal physiologically-based pharmacokinetic model. [PDF]
Cheng C, Jeong YS, Jusko WJ.
europepmc +1 more source
Gadolinium Pollution—A Future Forward Perspective on Human and Environmental Impact
ABSTRACT The widespread use of gadolinium‐based contrast agents (GBCAs) in magnetic resonance imaging (MRI) has been instrumental in enhancing diagnostic capabilities. However, the potential environmental and human health impacts of gadolinium pollution have become a growing concern.
Makayla R. Long +5 more
wiley +1 more source
When new therapies arrive, we should think more: The unseen challenges of immunotherapy-induced remodeling. [PDF]
Wang RG.
europepmc +1 more source
A Bear of a Case: Multidisciplinary Reconstruction Following a Grizzly Bear Mauling
ABSTRACT Grizzly bear attacks are rare but often result in devastating craniofacial injuries requiring staged, multidisciplinary reconstruction. A 61‐year‐old male sustained extensive facial trauma, including complete lower lip avulsion and anterior mandibular loss, after a grizzly bear attack.
Jacob Beiriger +5 more
wiley +1 more source
Improving In Vitro-In Vivo Correlation (IVIVC) for Lipid-Based Formulations: Overcoming Challenges and Exploring Opportunities. [PDF]
Bourderi-Cambon A +7 more
europepmc +1 more source

