Results 281 to 290 of about 26,404 (336)

[Intestinal absorption of daphnetin by rats single pass perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
This study investigated the effects of concentration, intestinal section, pH and P-gp on the absorption of daphnetin. The absorptions of three concentrations (10, 20, 40 microg x mL(-1)) of daphnetin in different intestinal segments were studied with phenol red as the marker by in situ rats single pass perfusion model. The results showed that daphnetin
Qiu, Du, Liu-Qing, Di, Jin-Jun, Shan, Tao-Shi, Liu, Xin-Zhuang, Zhang   +4 more
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Studies on intestinal absorption of alkaloids in Coptis chinensis by in situ single-pass perfused rat intestinal model

China Journal of Chinese Materia Medica, 2011
Objective To study the absorption characteristics of alkaloids in Coptis chinensis in rat intestinal. Method In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC, the drug absorption rate constant (K(a)) and apparent absorption coefficient (P(app)) were tested to ...
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[Intestinal absorption of berberine alone and in combinations by rats single pass intestinal perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
The aim of the study is to investigate the effects of concentration, intestinal segments, pH, inhibitors of proteins (P-gp), Na(+)-dependent glucose transporter (SGLT1) on the intestinal absorption of berberine, and to compare intestinal absorption of berberine in combinations. With phenol red as the indicator, in situ single pass intestinal perfusion (
Yan, Zhang, Hua-Xu, Zhu, Li-Wei, Guo
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Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.

Drug Metabolism and Disposition, 1986
The in situ perfused rat small intestine preparation was used to examine the extents of segmental absorption and metabolism of acetaminophen (A). Additionally, the preparation was employed to investigate any intestinal excretion of A and its conjugates from the circulation to the intestinal lumen.
K S, Pang, V, Yuen, S, Fayz, J M, te Koppele, G J, Mulder   +4 more
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[Absorption of flavonoids from Abelmoschus manihot extract by in situ intestinal perfusion].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
To explore the mechanism of the absorption of flavonoids from Abelmoschus manihot flowers, in situ intestinal recirculation was performed to study the effect of the absorption at different concentrations and different intestinal regions. To evaluate the conditions of the absorption of six flavonoids from Abelmoschus manihot flowers, the concentrations ...
Cai-fu, Xue, Jian-ming, Guo, Da-wei, Qian, Jin-ao, Duan, Yan, Shu   +4 more
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[Overall intestinal permeability of multiple components in lotus leaf by in situ single pass intestinal perfusion models].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018
To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater ...
Xiu-Wen, Yin, Cheng-Bo, Hou, Jiang-Peng, Chen, Meng, Pan, Xue-Lian, Li, Zi-Yu, Wang, Ling, Dong   +6 more
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Simultaneous determination of digoxin and permeability markers in rat in situ intestinal perfusion samples by RP-HPLC

Journal of Chromatography B, 2004
A simple, sensitive and specific reversed-phase high performance liquid chromatographic (RP-HPLC) assay for simultaneous determination of digoxin and permeability markers, in samples obtained from intestinal in situ single-pass perfusion studies, was developed and validated.
Manthena V S, Varma, Namita, Kapoor, Mahua, Sarkar, Ramesh, Panchagnula   +3 more
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In Situ Intestinal Perfusion in Rodents: Future Perspectives for Application on Absorption Studies and Classification of Drugs

Mini-Reviews in Medicinal Chemistry, 2017
In 1995, the Biopharmaceutics Classification System (BCS) was proposed by Amidon and colleagues as a tool that considers two important parameters regarding drugs: solubility and permeability. Since then, several methods for solubility and permeability studies have been developed for drug delivery and absorption prediction. In recent years, permeability
Thaisa Marinho, Dezani, Andre Bersani, Dezani, Monica Maria Coquemala, de Silva, Cristina Helena, Dos Reis Serra   +3 more
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[Studies on intestinal absorption of alkaloids in Coptis chinensis by in situ single-pass perfused rat intestinal model].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012
To study the absorption characteristics of alkaloids in Coptis chinensis in rat intestinal.In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC, the drug absorption rate constant (K(a)) and apparent absorption coefficient (P(app)) were tested to evaluate their absorption ...
Ying, Chen, Qing, Yang, Lijuan, Zou, Yujie, Li, Yiwei, Wang, Xiaogang, Weng, Wei, Men, Xiaoxin, Zhu   +7 more
openaire   +1 more source

[Absorption of zedoary oil in rat intestine using in situ single pass perfusion model].

Yao xue xue bao = Acta pharmaceutica Sinica, 2005
To study the absorption of zedoary oil in intestine of rat.In situ single pass perfusion model was used and the concentrations of three components in perfusate were determined by HPLC in combination with diode array detection.The P(app) s of curcumol, curdione and germacrone were all low and had no significant difference (P > 0.05) at zedoary oil ...
Jian, You, Qing-po, Li, Ying-wei, Yu, Fu-de, Cui   +3 more
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