Results 181 to 190 of about 11,428 (247)

Application of Physiologically-Based Pharmacokinetic (PBPK) Model in Drug Development and in Dietary Phytochemicals. [PDF]

Curr Pharmacol Rep
Chou P, Shannar A, Pan Y, Dave PD, Xu J, Kong AT.   +5 more
europepmc   +1 more source

From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research. [PDF]

Chin Med J (Engl)
Liu K, Chen X, Fan Z, Ren F, Liu J, Hu B.   +5 more
europepmc   +1 more source

Mangiferin in human disease: Multifaceted mechanisms and applications (Review). [PDF]

Int J Mol Med
Dai Y, Huang Q, Tan M, Wang Z, Jiang C, Liu Z, Zhang S, Song S.   +7 more
europepmc   +1 more source

Punicic acid ethyl ester, a superior absorption-enhancer over pomegranate seed oil, dramatically improves quercetin bioavailability <i>via</i> strong interaction and rapid lipolysis. [PDF]

Int J Pharm X
Ding Y, Gong J, Yang P, Zhao Z, Jiang Z, Yang X, Xu M, Guo X, Yan Y, Yao Q.   +9 more
europepmc   +1 more source

Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 2: implementation strategies. [PDF]

Front Transplant
Land WG, Linkermann A.
europepmc   +1 more source

Cancer-on-a-chip for precision cancer medicine.

Lab Chip
Liu L, Wang H, Chen R, Song Y, Wei W, Baek D, Gillin M, Kurabayashi K, Chen W.   +8 more
europepmc   +1 more source

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Estimation of human oral fraction dose absorbed of simvastatin from various formulations using in-situ single pass intestinal perfusion method

Drug Delivery Letters, 2023
SIM is a poorly water-soluble drug with dissolution-dependent bioavailability. A solid dispersion and self-emulsifying drug delivery system was developed, optimized, and evaluated to improve its bioavailability. The permeability coefficient in rats was
Madhu Verma, A. Nanda, Iti Chauhan, Mohd. Yasir, Sagarika Majhi, Rajkumari, Meenakshi Sharma   +6 more
semanticscholar   +2 more sources

The intestinal absorption properties of flavonoids in Hippophaë rhamnoides extracts by an in situ single-pass intestinal perfusion model

Journal of Asian Natural Products Research, 2019
The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaë rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and ...
Lei Xin, Xiao-hui Liu, Jun Yang, Hongyi Shen, G. Ji, Xiufeng Shi, Yan Xie   +6 more
semanticscholar   +3 more sources

Nanoparticulate tablet dosage form of lisofylline-linoleic acid conjugate for type 1 diabetes: in situ single-pass intestinal perfusion (SPIP) studies and pharmacokinetics in rat

AAPS PharmSciTech, 2021
Lisofylline (LSF) is an anti-inflammatory molecule with high aqueous solubility and rapid metabolic interconversion to its parent drug, pentoxifylline (PTX) resulting in very poor pharmacokinetic (PK) parameters, necessitating high dose and dosing ...
K. Italiya, A. K. Singh, Deepak Chitkara, A. Mittal   +3 more
semanticscholar   +3 more sources

Exploring the compatibility mechanism of ShengDiHuang Decoction based on the in situ single-pass intestinal perfusion model.

Biopharmaceutics & Drug Disposition, 2019
Affecting the absorption of active ingredients in the intestine serves as one of the important compatibility mechanisms of traditional Chinese medicine. The aim of this study was to investigate the compatibility mechanism of ShengDiHuang Decoction (SDHD)
Hui Yang, Qi Hao, Jiangxue Cheng, Mei Wang, Junbo Zou, Xiaofei Zhang, Dongyan Guo   +6 more
semanticscholar   +3 more sources