Results 191 to 200 of about 11,428 (247)
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Pharmaceutical Chemistry Journal, 2018
P-glycoprotein (P-gp) mediated efflux affects the pharmacokinetics of several drugs. By analogy to verapamil, 1,4-dihydropyridines (DHPs) have been widely studied as P-gp inhibitors. Previously, we have reported on two new DHPs: IA1(A) and IIA5(B) as inhibitors of human MRP1, an efflux protein closely related to P-gp.
K. Sirisha +5 more
semanticscholar +3 more sources
P-glycoprotein (P-gp) mediated efflux affects the pharmacokinetics of several drugs. By analogy to verapamil, 1,4-dihydropyridines (DHPs) have been widely studied as P-gp inhibitors. Previously, we have reported on two new DHPs: IA1(A) and IIA5(B) as inhibitors of human MRP1, an efflux protein closely related to P-gp.
K. Sirisha +5 more
semanticscholar +3 more sources
The American Journal of Chinese Medicine, 2017
The flower bud of Daphne genkwa (Genkwa Flos) is a commonly used herbal medicine in Asian countries. Luteolin and apigenin are two recognized active flavonoids in Genkwa Flos. The aim of this study was to investigate the intestinal absorption mechanisms of Genkwa Flos flavonoids using in situ single-pass intestinal perfusion rat model.
Xin He +3 more
semanticscholar +3 more sources
The flower bud of Daphne genkwa (Genkwa Flos) is a commonly used herbal medicine in Asian countries. Luteolin and apigenin are two recognized active flavonoids in Genkwa Flos. The aim of this study was to investigate the intestinal absorption mechanisms of Genkwa Flos flavonoids using in situ single-pass intestinal perfusion rat model.
Xin He +3 more
semanticscholar +3 more sources
Intestinal Permeability of Forskolin by In Situ Single Pass Perfusion in Rats
Planta Medica, 2012The intestinal permeability of forskolin was investigated using a single pass intestinal perfusion (SPIP) technique in rats. SPIP was performed in different intestinal segments (duodenum, jejunum, ileum, and colon) with three concentrations of forskolin (11.90, 29.75, and 59.90 µg/mL).
Zhen-Jun Liu1 +5 more
semanticscholar +3 more sources
Chinese Journal of Natural Medicines, 2014
To investigate the absorption characteristics of the total alkaloids from Mahoniae Caulis (TAMC) through the administration of monterpene absorption enhancers or protein inhibitors.The absorption behavior was investigated in an in situ single-pass intestinal perfusion (SPIP) assay in rats.The intestinal absorption of TAMC was much more than that of a ...
Yu-He Sun +8 more
semanticscholar +3 more sources
To investigate the absorption characteristics of the total alkaloids from Mahoniae Caulis (TAMC) through the administration of monterpene absorption enhancers or protein inhibitors.The absorption behavior was investigated in an in situ single-pass intestinal perfusion (SPIP) assay in rats.The intestinal absorption of TAMC was much more than that of a ...
Yu-He Sun +8 more
semanticscholar +3 more sources
Xenobiotica, 2017
1. Hesperetin (HDND) possesses extensive bioactivities, however, its poor solubility and low bioavailability limit its application. HDND-7, a derivative of HDND, has better solubility and high bioavailability. In this study, we investigated the intestinal absorption mechanisms of HDND-7. 2.
Ruonan Chen +8 more
semanticscholar +3 more sources
1. Hesperetin (HDND) possesses extensive bioactivities, however, its poor solubility and low bioavailability limit its application. HDND-7, a derivative of HDND, has better solubility and high bioavailability. In this study, we investigated the intestinal absorption mechanisms of HDND-7. 2.
Ruonan Chen +8 more
semanticscholar +3 more sources
In situ Single-Pass Perfused Rabbit Intestinal Study sample Analysis of Ractopamine by UPLC
Asian Journal of Research in Pharmaceutical SciencesIn recent years, the prediction of oral drug absorption in humans has been a challenge for researchers and many techniques for permeability studies have been developed for several purposes, including biowaiver processes.
Fathima Namzi, K. S, R. Rajeswari. K
semanticscholar +2 more sources
International Journal of Pharmaceutics, 2017
Traditionally, the colon is considered a secondary intestinal segment in the drug absorption process. However, in many cases the role of colonic drug permeability cannot be overlooked. The purpose of this research was to compare colon permeability data obtained using two different rat perfusion methods the single-pass intestinal perfusion (SPIP ...
Isabel Lozoya‐Agullo +10 more
semanticscholar +3 more sources
Traditionally, the colon is considered a secondary intestinal segment in the drug absorption process. However, in many cases the role of colonic drug permeability cannot be overlooked. The purpose of this research was to compare colon permeability data obtained using two different rat perfusion methods the single-pass intestinal perfusion (SPIP ...
Isabel Lozoya‐Agullo +10 more
semanticscholar +3 more sources
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
To study the compatibility rule of Simao Yongan Decoction,the rat single pass intestinal perfusion model in situ was used in this study. On the basis of early research,the five kinds of anti-inflammatory active ingredients,i.e. chlorogenic acid,liquiritin,hyperoside,angoroside C and isochlorogenic acid C in Simao Yongan Decoction were selected as ...
X. Yu +6 more
semanticscholar +3 more sources
To study the compatibility rule of Simao Yongan Decoction,the rat single pass intestinal perfusion model in situ was used in this study. On the basis of early research,the five kinds of anti-inflammatory active ingredients,i.e. chlorogenic acid,liquiritin,hyperoside,angoroside C and isochlorogenic acid C in Simao Yongan Decoction were selected as ...
X. Yu +6 more
semanticscholar +3 more sources
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
The intestinal absorption properties of four main effective components(gallic acid, ocinolglucoside, ethyl gallate and penta-O-galloyl-β-D-glucose) in Rhus chinensis extracts were investigated by in situ single-pass intestinal perfusion model in rats. The liquid accumulation of perfusion was corrected by gravimetry.
Xiaoying Wang +7 more
semanticscholar +3 more sources
The intestinal absorption properties of four main effective components(gallic acid, ocinolglucoside, ethyl gallate and penta-O-galloyl-β-D-glucose) in Rhus chinensis extracts were investigated by in situ single-pass intestinal perfusion model in rats. The liquid accumulation of perfusion was corrected by gravimetry.
Xiaoying Wang +7 more
semanticscholar +3 more sources
Recent Patents on Drug Delivery & Formulation, 2019
PURPOSE The purpose of the study was formulation development, optimization and evaluation of a Self-Emulsifying Drug Delivery System (SEDDS) of Simvastatin (SIM) for improvement in dissolution and bioavailability of SIM.
Madhu Verma, A. Nanda, Y. Kumar
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PURPOSE The purpose of the study was formulation development, optimization and evaluation of a Self-Emulsifying Drug Delivery System (SEDDS) of Simvastatin (SIM) for improvement in dissolution and bioavailability of SIM.
Madhu Verma, A. Nanda, Y. Kumar
semanticscholar +3 more sources