Results 201 to 210 of about 11,428 (247)

Prediction of Human Intestinal Absorption of the Prodrug Temocapril by In Situ Single-Pass Perfusion Using Rat Intestine with Modified Hydrolase Activity

Drug Metabolism and Disposition, 2011
Intestinal absorption of temocapril, a prodrug of temocaprilat, was evaluated in an in situ rat jejunal perfusion model under various conditions of luminal pH and in the presence and absence of carboxylesterase-mediated hydrolysis. Temocapril was more easily taken up by mucosal cells at a luminal pH of 5.4 than at pH 6.4 or 7.4 and was extensively ...
Takaaki Nozawa, T. Imai
semanticscholar   +3 more sources

Prediction of human absorption of a trioxane antimalarial drug (CDRI 99/411) using an in-house validated in situ single-pass intestinal perfusion model

Arzneimittelforschung, 2011
The aim of the study was to predict human intestinal permeability and the fraction absorbed of an oral dose of a promising trioxane anti-malarial drug (CDRI 99/411) using the single-pass intestinal perfusion technique (SPIP) in rats.Effective permeability coefficients (P eff) in anaesthetized rats were determined for marker compounds and the trioxane ...
S. Singh, Kushalkumar Patel, Tejaswini Pradhan, H. Siddiqui, Shio Kumar Singh   +4 more
semanticscholar   +3 more sources

Evaluation of the mass balance assumption with respect to the two-resistance model of intestinal absorption by using in situ single-pass intestinal perfusion of theophylline in rats.

Journal of Pharmaceutical Sciences, 1992
Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances. Typically, a two-resistance model is used to determine the dimensionless effective permeability (P*eff) by measuring the disappearance of drug from the perfusing ...
K. Dackson, K. Dackson, J. A. Stone, J. A. Stone, K. Palin, W. Charman, W. Charman   +6 more
semanticscholar   +3 more sources

Effect of Vitamin C on Absorption Characteristics of Nimodipine and Nitrendipine in an in Situ Rat Single-Pass Intestinal Perfusion Model

SSRN Electronic Journal, 2022
Xianxin Meng, Guanjun Nan, Wanlu Li, Henglin Liu, Yiping Li, Jianyu He, Guangde Yang   +6 more
semanticscholar   +2 more sources

Assessment of intestinal absorption of O-glycoside flavonoid avicularin using in situ single-pass intestinal perfusion technique

Planta Medica, 2012
G. Buqui, D. Silva, A. Diniz, N. Lopes
semanticscholar   +2 more sources

Evaluation of Intestinal Drug Absorption and Interaction Using Quadruple Single-Pass Intestinal Perfusion Coupled with Mass Spectrometry Imaging.

Analytical Chemistry, 2023
Visualization and characterization of the intestinal membrane transporter-mediated drug absorption and interaction are challenging due to the complex physical and chemical environment.
Weiwei Tang, Yuejie Zhang, Ping Li, Bin Li   +3 more
semanticscholar   +1 more source

[Intestinal absorption of daphnetin by rats single pass perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
This study investigated the effects of concentration, intestinal section, pH and P-gp on the absorption of daphnetin. The absorptions of three concentrations (10, 20, 40 microg x mL(-1)) of daphnetin in different intestinal segments were studied with phenol red as the marker by in situ rats single pass perfusion model. The results showed that daphnetin
Qiu, Du, Liu-Qing, Di, Jin-Jun, Shan, Tao-Shi, Liu, Xin-Zhuang, Zhang   +4 more
openaire   +1 more source

Studies on intestinal absorption of alkaloids in Coptis chinensis by in situ single-pass perfused rat intestinal model

China Journal of Chinese Materia Medica, 2011
Objective To study the absorption characteristics of alkaloids in Coptis chinensis in rat intestinal. Method In situ single-pass perfused rat intestinal model was used and the concentrations of berberine and palmatine were determined by HPLC, the drug absorption rate constant (K(a)) and apparent absorption coefficient (P(app)) were tested to ...
openaire   +1 more source

Anin situsingle-pass perfusion model for assessing absorption across the intestinal mucosa of the brushtail possum

New Zealand Veterinary Journal, 2005
To develop an in situ animal model for assessing absorption of molecules across the intestinal mucosa of possums.A surgical preparation was used to perfuse known concentrations of reference compounds (fluorescein and luteinising hormone-releasing hormone; LHRH) through measured sections of selected regions (jejunum, caecum, proximal colon) of the ...
B J, McLeod, H, Zhang, L, Huang, E G, Thompson, A G, Butt, I G, Tucker   +5 more
openaire   +2 more sources

[Intestinal absorption of berberine alone and in combinations by rats single pass intestinal perfusion in situ].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
The aim of the study is to investigate the effects of concentration, intestinal segments, pH, inhibitors of proteins (P-gp), Na(+)-dependent glucose transporter (SGLT1) on the intestinal absorption of berberine, and to compare intestinal absorption of berberine in combinations. With phenol red as the indicator, in situ single pass intestinal perfusion (
Yan, Zhang, Hua-Xu, Zhu, Li-Wei, Guo
openaire   +1 more source